In this episode of the Vibrant Wellness podcast, host Dr. Emmie Brown is joined by Dr. Kyle Gillett, founder of Gillett Health and a leader in holistic, evidence-based longevity medicine, where he shares expertise in hormone and peptide therapies, preventive medicine, sports medicine, and genomics.
Dr. Gillett unpacks common misconceptions in hormone therapy, including the often-misunderstood distinctions between bioidentical and synthetic hormones, as well as compounded versus commercial formulations. He explains how different testing methods—serum, saliva, and urine—each provide unique insights. The discussion highlights the importance of comprehensive intake assessments and lab panels tailored to individual goals, focusing on body composition, cardiovascular health, or cancer prevention. Throughout, he emphasizes that hormone optimization is not one-size-fits-all, with factors like SHBG levels, route of administration, and patient history shaping safe and effective protocols.
Moving beyond hormones, Dr. Gillett explores peptide therapies and their potential role in supporting recovery, body composition, and longevity—while cautioning against their misuse without proper testing and safety measures. He underscores that lifestyle foundations such as sleep, nutrition, exercise, and social health remain more powerful than any therapy, with peptides serving only as supportive tools once the basics are in place. The episode also touches on exercise and longevity research, including the rise of hybrid athlete training and the benefits of creatine across populations. Listeners will discover how thoughtful, evidence-based approaches can create more sustainable pathways toward healthspan and vitality.
🎙 Key Topics Covered
⚙️ Hormone testing explained: serum = fuel, saliva/urine = exhaust
💊 Common misconceptions in hormone therapy: bioidentical vs. synthetic
⏳ The “anti-aging” debate: cosmetic, functional & cellular distinctions
📊 Personalized lab testing & intake: panels, goals & health tracks
🧬 Hormone testing methods: strengths of serum, saliva & urine
🧴 HRT protocols: SHBG levels, topical vs. injectable considerations
🧩 Peptide therapies: safety, lab markers & clinical applications
🌱 Lifestyle as the foundation: sleep, diet, exercise & social health
🏋️ Longevity & training: hybrid athlete model, creatine & future therapies
⏱️ Timestamps
0:00 – Welcome + guest intro: Dr. Kyle Gillett, founder of Gillett Health
0:33 – Biggest misconceptions in hormone therapy and anti-aging practices
2:05 – Bioidentical vs. synthetic hormones + compounded vs. commercial products
3:51 – The “anti-aging” debate: cosmetic, functional & cellular distinctions
6:30 – Lab testing & intake process: patient goals, history, and executive tracks
9:44 – Personalized lab panels: athlete panels, cancer detection, specialty add-ons
13:17 – Hormone testing explained: serum (fuel) vs. saliva/urine (exhaust)
15:11 – Sex hormone metabolism & what urine testing reveals
18:21 – HRT protocols: SHBG, topical vs. injectable testosterone, individualized care
20:46 – Peptide therapies: lab markers, safety considerations & clinical examples
25:23 – Lifestyle as the foundation: the “80/20 rule,” sleep, diet, exercise & social health
30:05 – Longevity & training: hybrid athlete model, creatine research, emerging therapies
37:12 – Case study: postmenopausal female with individualized cyclical HRT
41:34 – Practitioner education: CME events, training resources & textbook basics
43:28 – Closing remarks + where to connect with Dr. Kyle Gillett
🔗 Resources Mentioned
🌐 Dr. Kyle Gillett's Website: https://gilletthealth.com/
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Limitations
Please note the information provided by Vibrant Wellness is intended solely for research and informational purposes to help inform lifestyle choices aimed at potential risk mitigation. The information is not intended to be used by the patient for any diagnostic purpose and is not a substitute for medical advice by a healthcare practitioner. Please consult a licensed healthcare practitioner for any questions regarding diagnosis, prevention, or treatment of any disease or health assessment.