In this episode of the Vibrant Wellness Podcast, Dr. Philip Oubre sits down with Dr. Jeffrey Gladden, a leader in longevity and preventive medicine and founder of Gladden Longevity & Advanced Performance Center, to challenge everything we think we know about aging. Dr. Gladden shares his transformation from decades in interventional cardiology to becoming a pioneer of true “health care,” after facing his own decline in energy, mood, and performance.
Dr. Oubre and Dr. Gladden explore the mindset shift that occurs when medicine stops treating disease and starts optimizing human potential. They unpack the five circles of longevity: life energy, health, longevity biology, performance, and environment, and explain how each interlocks to extend both lifespan and healthspan. They discuss approaches ranging from addressing cellular aging markers such as mitochondrial function and inflammation to rebuilding vascular health through the glycocalyx and nitric oxide pathways.
The episode also explores mindset and emotional health, describing how trauma, anxiety, and lack of safety shape the nervous system, and why healing at that level is vital for longevity. Dr. Gladden highlights that living with curiosity, compassion, and purpose reprograms the mind and body toward resilience. Pushing the limits of what is possible, Dr. Oubre and Dr. Gladden discuss innovative research in stem cells, exosomes, and epigenetic reprogramming that may soon reverse biological aging itself. Their conversation encourages listeners to stay curious, question assumptions, and see discomfort as an opportunity for growth.
🌍 The shift from “sick care” to true health optimization and longevity
❓ Why all progress comes from the questions, not the answers
🧬 Using genetics and biometric testing to uncover hidden dysfunctions
💪 Building a 100-year-old body through VO₂ max, strength, and balance training
❤️ The overlooked power of the glycocalyx in cardiovascular and sexual health
🧘♀️ Healing trauma, finding safety, and cultivating a 300-year-old mind
🔥 Embracing discomfort: fasting, cold, heat, and hormetic stress as longevity tools
🚀 The future of aging reversal: stem cells, exosomes, and epigenetic reprogramming
0:00 – Welcome to Vibrant Wellness with Dr. Jeffrey Gladden
3:30 – The Wake-Up Call: When “You’re Just Getting Older” Isn’t an Answer
6:00 – Discovering Functional Medicine and Biometric Testing
9:30 – How Genetics Changed Everything
10:30 – Hormones, Thyroid, and the Missing Links in Men’s Health
12:00 – From Sick Care to Health Care: The Turning Point
14:00 – All Progress Comes from the Questions, Not the Answers
17:00 – Curiosity: The Real Fountain of Youth
18:30 – Building a 100-Year-Old Body with a 300-Year-Old Mind
20:00 – The Five Circles of Longevity
22:45 – The Fear of Decline & Redefining Aging
26:00 – Healing Trauma and Living Unencumbered
28:30 – Safety, Love, and the True Meaning of Longevity
34:00 – Mind-Body Connection and Healing at the Nervous System Level
35:00 – Erectile Dysfunction, Vascular Health, and Psychological Roots
37:00 – The Glycocalyx: The Secret Layer Protecting Your Arteries
42:00 – How to Boost Nitric Oxide Naturally
45:00 – Why Discomfort Keeps You Young
47:30 – Zone 2 vs Zone 3 Training: The Truth About VO₂ Max
50:30 – Longevity Training for Women
55:00 – Real-Life Transformations: From Fatigue to Peak Performance
01:00:00 – The Future of Medicine: Central Reprogramming & Quantum Health
01:08:00 – Why Aging Could Be Reversed Within 3 Years
01:09:30 – Final Thoughts: Stay Curious, Stay Young
Resources Mentioned
🌐 Learn more about Gladden Longevity
📱 Gladden Longevity on Instagram
📎 Connect with Dr. Philip Oubre on LinkedIn
Follow us on:
🐦 X/Twitter: https://x.com/Vibrant_lab
📸 Instagram: https://instagram.com/vibrantlabs/
📘 Facebook: https://facebook.com/VibrantAmerica
💼 LinkedIn: https://linkedin.com/company/vibrantwellness
📧 Contact Us: support@vibrant-wellness.com
Join Over 18,000 Leading Medical Professionals and Become a Vibrant Wellness Provider Today!
Limitations
Please note the information provided by Vibrant Wellness is intended solely for research and informational purposes to help inform lifestyle choices aimed at potential risk mitigation. The information is not intended to be used by the patient for any diagnostic purpose and is not a substitute for medical advice by a healthcare practitioner. Please consult a licensed healthcare practitioner for any questions regarding diagnosis, prevention, or treatment of any disease or health assessment.