What is rs2108622 (CYP4F2) nd Why Does the Nutrient Zoomer Test for It?

Vitamin K–fatty acid oxidase

rs2108622 is a common genetic variant in the CYP4F2 gene, which encodes a cytochrome P450 enzyme that metabolizes vitamin K and certain long-chain fatty acids. Knowing this variant helps explain individual differences in how the body handles fat‑soluble nutrients and related lipid metabolites, improving interpretation of nutrient test results.

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rs2108622 (CYP4F2)

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About rs2108622 (CYP4F2)

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About rs2108622 (CYP4F2)

Overview and History

CYP4F2 is part of the cytochrome P450 family of enzymes and functions as an omega‑hydroxylase that acts on fat‑soluble vitamins and long‑chain fatty acids. The rs2108622 change (often referred to by its protein change V433M) alters enzyme activity in many people and has been studied in pharmacogenetics and nutrient metabolism research. Clinically, CYP4F2’s biochemical roles include oxidative processing of vitamin K1, tocopherols, and select eicosanoids. Variants that change CYP4F2 activity can shift circulating and tissue patterns of these compounds, so the marker is useful for explaining interindividual variation in nutrient and lipid biomarkers measured by advanced panels.

Interpreting Highs and Lows

Variants associated with increased CYP4F2 activity tend to be linked with more rapid oxidative clearance of vitamin K–type compounds and certain fatty‑acid metabolites; in a testing context this can appear alongside lower measured vitamin K–related markers or altered eicosanoid ratios. Variants associated with reduced activity are often linked with relative retention of vitamin K and altered fatty‑acid metabolite patterns, which can show as higher vitamin K–related measures or shifts in fatty‑acid metabolite ratios. Interpretation of these patterns is most reliable when viewed with the complete Nutrient Zoomer panel (fat‑soluble vitamin levels, fatty‑acid profiles, and related nutrient genes) and clinical context rather than any single value alone.

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rs2108622 (CYP4F2) is included because it helps explain inherited differences in vitamin K and long‑chain fatty‑acid handling. As a genetic lens on fat‑soluble nutrient metabolism, it complements measured vitamin and lipid markers to clarify why individuals with similar diets show different nutrient patterns, supporting more personalized nutritional assessment.

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rs2108622 (CYP4F2) FAQs

What is rs2108622 (CYP4F2) and why is it important?

rs2108622 is a common genetic variant in the CYP4F2 gene, which makes an enzyme that modifies fat‑soluble vitamins and some fatty acids. The variant can change how quickly these compounds are processed in the body, so knowing your rs2108622 status helps explain variations in vitamin K, vitamin E, and lipid metabolite measurements. That context helps providers interpret nutrient testing more accurately.

What does it mean if my rs2108622 (CYP4F2) levels are low?

If your results suggest lower CYP4F2 activity, it is commonly associated with slower oxidative processing of vitamin K–type compounds and some fatty‑acid metabolites. In testing this can appear alongside relatively higher vitamin K–related markers or shifts in fatty‑acid metabolite ratios. These findings are associative and should be evaluated alongside the full Nutrient Zoomer results and clinical context.

What does it mean if my rs2108622 (CYP4F2) levels are high?

If your results suggest higher CYP4F2 activity, it is commonly associated with faster oxidative clearance of vitamin K–type compounds and certain fatty‑acid metabolites. In the lab this can present with lower measured vitamin K–related markers or different eicosanoid and fatty‑acid patterns. Clinical interpretation requires correlation with the rest of the nutrient panel and individual factors.

Why is rs2108622 (CYP4F2) included in the Nutrient Zoomer?

Including rs2108622 adds a genetic perspective on fat‑soluble vitamin and fatty‑acid metabolism, helping providers explain unexpected nutrient results and identify patterns of altered nutrient handling. Paired with measured vitamins, fatty acids, and other nutrient genes, it supports more precise, individualized interpretation of nutrient status.

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