What is rs6139591 (SLC23A2) nd Why Does the Nutrient Zoomer Test for It?

Vitamin C transporter variant

rs6139591 is a single-nucleotide variant in the SLC23A2 gene, which encodes the SVCT2 sodium-dependent vitamin C transporter. SVCT2 helps move vitamin C into many tissues; testing this variant can help explain differences in cellular vitamin C uptake and nutrient handling between individuals.

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rs6139591 (SLC23A2)

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About rs6139591 (SLC23A2)

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About rs6139591 (SLC23A2)

Overview and History

rs6139591 is a single-nucleotide polymorphism (SNP) located in SLC23A2, the gene that encodes the SVCT2 transporter. SVCT2 belongs to the sodium-dependent vitamin C transporter family and is widely expressed in tissues that actively accumulate ascorbate. Researchers have studied SLC23A2 variants because SVCT2 function influences how cells acquire vitamin C, a molecule that acts as an antioxidant and cofactor for multiple enzymatic reactions. Variants in SLC23A2 have been linked in research to variation in tissue or plasma vitamin C measures and to differences in biomarker patterns related to oxidative and nutrient biology.

Interpreting Highs and Lows

Genetic variants associated with reduced SVCT2 expression or function may be accompanied by lower cellular vitamin C uptake and may correlate with lower tissue or functional vitamin C measures on biochemical testing. Conversely, variants linked to preserved or higher transporter activity may be associated with relatively greater cellular ascorbate availability. Interpretation of any association requires the full Nutrient Zoomer context—measured vitamin C levels, other nutrient and transporter markers, and clinical factors influence meaning more than genotype alone.

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This genetic marker is included to clarify inherited effects on vitamin C transport. When combined with measured vitamin C and related nutrient markers, rs6139591 helps explain interpersonal differences in uptake and usage, supporting more precise interpretation of nutrient status for personalized care.

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rs6139591 (SLC23A2) FAQs

What is rs6139591 (SLC23A2) and why is it important?

rs6139591 is a common genetic variant in the SLC23A2 gene that can influence the SVCT2 vitamin C transporter. Because SVCT2 helps move vitamin C into cells, differences at this site can partly explain why people with similar diets or blood levels may vary in tissue vitamin C availability. Knowing your genotype adds context to measured nutrient results and helps clarify individual nutrient-processing patterns.

What does it mean if my rs6139591 (SLC23A2) levels are low?

For a genetic marker, “low” typically refers to having an allele associated with reduced transporter activity or expression. That pattern can be associated with lower cellular uptake of vitamin C and may align with lower tissue or functional vitamin C measures on the full panel. Any single genetic association is best interpreted alongside blood nutrient measurements and other results.

What does it mean if my rs6139591 (SLC23A2) levels are high?

If your genotype includes alleles linked to preserved or increased SVCT2 function, it may be associated with relatively greater cellular vitamin C uptake. Elevated-function associations can influence how measured vitamin C levels translate into tissue availability, but clinical interpretation requires the broader Nutrient Zoomer profile and clinical context.

Why is this biomarker included in the Nutrient Zoomer?

rs6139591 is part of the nutrient-processing genetics layer that explains variability in vitamin C transport. Combined with direct vitamin C measurement and related markers, it helps providers detect patterns of altered uptake, interpret discordant results, and tailor monitoring and nutritional planning based on inherited predispositions.

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