What is rs778479139 (SLC52A3) nd Why Does the Nutrient Zoomer Test for It?

Riboflavin transporter variant

rs778479139 is a genetic variant in SLC52A3, the gene for an intestinal riboflavin (vitamin B2) transporter. It can influence how well the body absorbs and moves riboflavin, a precursor for cofactors used in energy production and redox chemistry. Measuring this variant helps explain individual differences in riboflavin status and related metabolic patterns.

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rs778479139 (SLC52A3)

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About rs778479139 (SLC52A3)

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About rs778479139 (SLC52A3)

Overview and History

rs778479139 is a single-nucleotide variant in SLC52A3, a member of the solute carrier 52 family that encodes the RFVT3 riboflavin transporter. SLC52A3 was identified through molecular studies of intestinal transport and has been studied for its role in systemic riboflavin delivery and clinical associations with altered flavin metabolism. Biologically, the SLC52A3 protein mediates riboflavin uptake across the intestinal epithelium and contributes to tissue access to riboflavin-derived cofactors (FMN, FAD). Those cofactors are essential for mitochondrial energy enzymes, antioxidant systems, and many oxidation–reduction reactions, so variation in transporter function can shift cellular cofactor availability and downstream metabolic processes.

Interpreting Highs and Lows

Interpreting this variant depends on functional effect: genotypes associated with reduced SLC52A3 activity may be linked to lower riboflavin uptake and lower availability of FMN/FAD-dependent cofactors; genotypes associated with normal or increased activity suggest typical riboflavin transport. Genetic effect sizes vary and actual nutrient status also depends on diet, other transporters and enzymes, and clinical markers. Because a single genetic variant is only one piece of the picture, results are best interpreted alongside blood riboflavin measures, functional assays (for example flavin-dependent enzyme activity), and the broader Nutrient Zoomer pattern to identify meaningful nutrient handling differences.

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Nutrient Zoomer includes rs778479139 to clarify inherited differences in riboflavin transport that can influence B2-dependent metabolism. By linking this genetic marker with blood flavin measures and functional indicators, providers can better explain atypical nutrient patterns and tailor nutrition-focused strategies to an individual’s biochemical profile.

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rs778479139 (SLC52A3) FAQs

What is rs778479139 (SLC52A3) and why is it important?

rs778479139 is a genetic variant in the SLC52A3 gene, which encodes a protein that transports riboflavin (vitamin B2) across the gut. Riboflavin is needed to make FMN and FAD, cofactors for many energy and antioxidant enzymes. Knowing whether this variant is present helps explain why two people with similar diets might show different riboflavin-related lab results or metabolic patterns.

What does it mean if my rs778479139 (SLC52A3) levels are low?

Genetic reports typically describe reduced-function genotypes rather than ‘levels.’ A genotype linked to lower SLC52A3 activity may be associated with reduced intestinal riboflavin uptake and lower availability of flavin cofactors. That pattern can show up as low riboflavin or altered functional markers on the full Nutrient Zoomer panel, but interpretation requires considering diet, other genes, and laboratory results.

What does it mean if my rs778479139 (SLC52A3) levels are high?

A genotype associated with normal or higher SLC52A3 activity suggests effective riboflavin transport capacity, which may support adequate flavin cofactor availability under typical dietary intake. However, measured nutrient status still depends on intake, absorption, and other metabolic factors, so genetic indication of higher transporter activity should be evaluated together with blood and functional markers.

Why is this biomarker included in the Nutrient Zoomer?

rs778479139 helps explain inherited differences in how the body handles riboflavin, clarifying why blood flavin measures or functional assays may not match dietary intake. Including this marker with direct nutrient and functional tests improves pattern recognition and supports more precise, individualized nutrition assessment.

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