What is Verrucarin A? And Why Does the Toxin Zoomer Test for It?

Macrocyclic trichothecene mycotoxin

Verrucarin A is a mold-derived macrocyclic trichothecene produced by certain filamentous fungi. It can disrupt basic cellular processes in lab studies, so measuring it in urine provides a marker of recent exposure to mold-related toxins and contributes to an overall view of toxic burden.

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Verrucarin A

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About Verrucarin A

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About Verrucarin A

Overview and History

Verrucarin A is classified as a macrocyclic trichothecene mycotoxin, a type of secondary metabolite produced by some filamentous fungi. It was first identified from environmental fungal isolates and has been characterized in toxicology and environmental studies as a biologically active fungal product. As a small, lipophilic molecule with a macrocyclic ring, Verrucarin A interacts with cellular machinery in experimental systems. Laboratory research has shown it can interfere with protein production and activate cellular stress pathways, which is why it is measured as a marker of mold-related exposure in environmental toxicology.

Interpreting Highs and Lows

Elevated urinary Verrucarin A may indicate recent or ongoing exposure to molds that produce macrocyclic trichothecenes or to contaminated food or materials, and can reflect an increased mycotoxin component of a person’s toxic burden. Low or undetectable levels generally suggest little recent exposure or effective elimination but do not exclude past or intermittent exposure to other mycotoxins. As with all Toxin Zoomer results, interpretation is most accurate when considered alongside other toxicant measurements, exposure history, and detoxification genetics.

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Verrucarin A is included in the Toxin Zoomer to detect exposure to a specific class of mold-derived mycotoxins. Its measurement helps link laboratory evidence of mycotoxin burden to likely environmental or dietary sources and to a person’s detoxification profile, supporting targeted assessment of exposure patterns and personalized follow-up.

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Verrucarin A FAQs

What is Verrucarin A and why is it important?

Verrucarin A is a toxin made by certain molds. It has biological activity in lab studies and is used as a marker of mold-related exposure. Detecting it in urine helps clinicians identify possible environmental or food sources of mycotoxin exposure and compare that signal with other toxicants and genetic factors.

What does it mean if my Verrucarin A levels are low?

Low or undetectable Verrucarin A usually means little recent exposure to molds that produce macrocyclic trichothecenes or that the compound has been cleared from the body. However, low levels don’t rule out past, intermittent, or other types of mycotoxin exposure. Full interpretation requires comparing this result with other panel markers, exposure history, and detoxification genetics.

What does it mean if my Verrucarin A levels are high?

Higher Verrucarin A levels suggest recent or ongoing exposure to molds producing macrocyclic trichothecenes or to contaminated food or materials and may reflect a greater mycotoxin component of toxic burden. Elevated values need to be interpreted in clinical context alongside other toxicants, exposure history, and detox-related genetics to clarify likely sources and persistence.

Why is Verrucarin A included in the Toxin Zoomer?

Measuring Verrucarin A adds specificity for mold-derived macrocyclic trichothecenes within the panel’s broader toxicant map. This helps providers detect exposure patterns, relate mycotoxin burden to detoxification genetics, and prioritize which environmental sources or follow-up assessments may be most relevant.

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