Noncoding cardiovascular risk locus
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About 9p21 region – rs10116277, rs4977574, rs1333049, rs10757278, rs2383207, rs2383206
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About 9p21 region – rs10116277, rs4977574, rs1333049, rs10757278, rs2383207, rs2383206
Overview and History
These markers are single‑nucleotide polymorphisms (SNPs) clustered in the 9p21 chromosomal region. They are noncoding variants identified by genome‑wide association studies (first noted in large studies in the mid‑2000s) that consistently associate with cardiovascular risk patterns across populations.
Biologically, the 9p21 locus sits beside regulatory elements and genes such as CDKN2A, CDKN2B and the long noncoding RNA ANRIL. Experimental and population studies link this region to effects on cell cycle control, vascular cell proliferation, and local inflammatory signaling, though exact molecular mechanisms remain an area of active research.
Interpreting Highs and Lows
Because these are genetic variants rather than circulating molecules, “elevated” refers to having more risk alleles or a higher inherited‑risk score at the 9p21 locus. A higher burden of risk alleles is associated with stronger inherited predisposition toward adverse cardiovascular patterns; a lower burden indicates relatively less inherited contribution from this locus. Interpretation should always be done alongside Cardio Zoomer’s biochemical, metabolic, and vascular markers and with clinical context, since genetics is only one piece of overall cardiovascular risk.
Featured Test
Cardio Zoomer includes the 9p21 SNPs to quantify an individual’s inherited propensity linked to vascular biology and cardiovascular risk patterns. These variants provide genetic context that complements lipids, inflammation, endothelial and metabolic markers—helping clinicians distinguish inherited tendencies from acquired drivers and personalize monitoring and prevention strategies.
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