ACE gene functional variant
Quality and Security
High-quality testing run in a CLIA-certified and CAP-accredited lab in Santa Clara, California.
About ACE – rs4343, rs4646994
${ activeTab.tab_content.text }
Loading...
About ACE – rs4343, rs4646994
Overview and History
rs4343 is a single‑nucleotide polymorphism (SNP) and rs4646994 is the well‑studied insertion/deletion (I/D) polymorphism in the ACE gene. The I/D variant was identified in genetic research in the 1990s and has been widely used as a marker for inherited differences in circulating and tissue ACE levels; rs4343 often serves as a tagging SNP in linkage studies.
Biologically, ACE is a zinc‑dependent peptidyl dipeptidase expressed on vascular endothelium and in many tissues. Its main actions are converting angiotensin I to angiotensin II, a potent vasoactive peptide, and degrading bradykinin, a vasodilator; both actions influence vascular tone, sodium handling, and cell signaling related to vascular remodeling and inflammation.
Interpreting Highs and Lows
Genotypes associated with higher ACE activity may be linked to stronger angiotensin II signaling and reduced bradykinin availability; in biomarker panels this can show up alongside higher measures of vascular tone or related stress markers. Genotypes associated with lower ACE activity may show the opposite pattern, with relatively reduced angiotensin II formation. Interpreting either pattern requires the full Cardio Zoomer profile—blood pressure, endothelial markers, inflammatory and oxidative stress markers, and other genetic variants—to understand how the ACE signal interacts with other pathways.
Featured Test
Cardio Zoomer includes these ACE variants to capture inherited tendencies in the renin‑angiotensin system. Knowing a patient’s ACE genotype helps clinicians interpret vascular tone, endothelial function, and related biomarker patterns, adding genetic context to biochemical and clinical data for more informed, individualized assessment.
Related Articles
Cardiovascular disease remains the leading cause of death worldwide, yet most testing still focuses on surface-level metrics like total cholesterol or...
What do you think of when you hear the term “cardiovascular disease?” Most people immediately think of high cholesterol, but cardiovascular risk goes ...
A common theme among many of my nutrition clients is that despite eating well, staying active, and managing stress, they feel worn down, inflamed, and...
When it comes to cardiovascular disease (CVD), many people immediately think of high cholesterol. High cholesterol—a specific type of dyslipidemia or ...
Results trusted by over 18,000 functional wellness professionals
We’re the leading provider of specialty wellness lab testing because we develop our testing with rigorous, ongoing research by top clinical experts, doctors, and scientists.
-1.png?width=542&height=427&name=shutterstock_2371998817%201%20(1)-1.png)
.png?width=207&height=108&name=Group%201410104259%20(1).png)
The gold standard of accuracy in the lab industry
Our tests run on a proprietary 3Dense microchip technology platform that boasts unrivaled specificity and sensitivity. While most other labs carry only CLIA certification, we're CAP-accredited by the College of American Pathologists.
.png?width=487&height=356&name=Frame%201410104197%20(3).png)
.png?width=187&height=63&name=category%20Card%20text%20(1).png)
.png?width=202&height=63&name=category%20Card%20text%20(2).png)
Mary Beth Augustine
DCN, RDN, FAND- Lead Clinical Educator
Suzanne Barker
MS, RDN, LD, CTTS, CGP- Clinical Educator
Suzette Garcia
MSc- MHNE- Clinical Educator
Brooke Mader Ganev
MS, CNS, LDN, FDN- Clinical Educator
Adair Anderson
MS, RDN, LDN- Clinical Educator
Lillie Luu Nguyen
DCN, CNS, LDN- Clinical Educator
Jason Barker
ND- Clinical Educator
Emaline Brown
ND- Clinical Educator
Dana Filatova
DCN, CNS, LDN- Clinical Educator
Jessy Dhanjal
ND- Clinical Educator
Nour Amri
MS, LDN, CNS, CKNS- Clinical Educator
