9p21 noncoding RNA variant
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About CDKN2B-AS1 – rs10757274
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About CDKN2B-AS1 – rs10757274
Overview and History
CDKN2B-AS1 – rs10757274 is a single-nucleotide polymorphism (SNP) located in the long noncoding RNA region known as CDKN2B-AS1 (often called ANRIL) on chromosome 9p21. It is a common genetic variant identified and replicated in large genome-wide association studies as being linked to population-level differences in cardiovascular-related traits.
Biologically, this locus modulates expression of neighboring genes such as CDKN2A and CDKN2B, which regulate cell-cycle control, cellular senescence, and vascular cell proliferation. Through effects on gene regulation and local chromatin structure, variants at 9p21 are thought to influence vascular cell behavior and inflammatory signaling pathways relevant to arterial biology.
Interpreting Highs and Lows
For a genetic marker like rs10757274, “elevated” typically means carrying the allele that studies associate with higher cardiovascular-related patterns; this is interpreted as a stronger inherited tendency, not a diagnosis. Presence of the risk-associated allele may correlate with patterns such as altered vascular cell proliferation, inflammation signaling, or plaque-prone biology when seen with other abnormal markers. Conversely, absence of the risk allele (a “low” or non-risk genotype) suggests a lower inherited contribution from this specific locus but does not rule out risk driven by other genes, lifestyle, or laboratory findings. Always interpret the genotype alongside the full Cardio Zoomer panel and clinical context.
Featured Test
Cardio Zoomer includes rs10757274 to capture an inherited genetic influence on vascular biology and cell-cycle regulation. This marker helps explain why some individuals show certain lipid, inflammatory, or endothelial patterns despite similar clinical measures, supporting more personalized risk assessment and monitoring strategies.
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Mary Beth Augustine
DCN, RDN, FAND- Lead Clinical Educator
Suzanne Barker
MS, RDN, LD, CTTS, CGP- Clinical Educator
Suzette Garcia
MSc- MHNE- Clinical Educator
Brooke Mader Ganev
MS, CNS, LDN, FDN- Clinical Educator
Adair Anderson
MS, RDN, LDN- Clinical Educator
Lillie Luu Nguyen
DCN, CNS, LDN- Clinical Educator
Jason Barker
ND- Clinical Educator
Emaline Brown
ND- Clinical Educator
Dana Filatova
DCN, CNS, LDN- Clinical Educator
Jessy Dhanjal
ND- Clinical Educator
Nour Amri
MS, LDN, CNS, CKNS- Clinical Educator
