COX-1 gene variant
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About COX-1 – rs1330344
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About COX-1 – rs1330344
Overview and History
rs1330344 is a single nucleotide polymorphism (SNP) in the PTGS1 gene, commonly referred to as COX‑1. As a genetic marker, it sits in or near regulatory regions of the gene and is studied as a common variation rather than a rare mutation.
COX‑1 encodes the constitutive cyclooxygenase enzyme that converts arachidonic acid into prostaglandin H2, the precursor for prostaglandins and thromboxane A2. These lipid mediators modulate platelet activation, local inflammation, and vascular tone, so genetic differences in PTGS1 have been explored for their effects on platelet biology and drug response in clinical studies.
Interpreting Highs and Lows
For genetic markers like rs1330344, “high” or “low” refers to the presence or number of variant alleles. Genotypes carrying one or two copies of the variant allele have been associated in studies with modest differences in COX‑1 expression or platelet reactivity, while absence of the variant aligns with the reference allele pattern.
These associations are population-level patterns, not direct measures of current enzyme activity. Interpretation should be made alongside functional biomarkers (platelet function, thromboxane metabolites, inflammation, lipids) and clinical context to understand whether the variant meaningfully contributes to an individual’s cardiovascular profile.
Featured Test
Cardio Zoomer includes rs1330344 to add inherited context for prostaglandin/thromboxane signaling and platelet biology. Paired with functional labs in the panel, this genetic information helps clinicians distinguish inherited tendencies from acquired changes, supporting more precise interpretation of clotting and inflammatory patterns.
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Mary Beth Augustine
DCN, RDN, FAND- Lead Clinical Educator
Suzanne Barker
MS, RDN, LD, CTTS, CGP- Clinical Educator
Suzette Garcia
MSc- MHNE- Clinical Educator
Brooke Mader Ganev
MS, CNS, LDN, FDN- Clinical Educator
Adair Anderson
MS, RDN, LDN- Clinical Educator
Lillie Luu Nguyen
DCN, CNS, LDN- Clinical Educator
Jason Barker
ND- Clinical Educator
Emaline Brown
ND- Clinical Educator
Dana Filatova
DCN, CNS, LDN- Clinical Educator
Jessy Dhanjal
ND- Clinical Educator
Nour Amri
MS, LDN, CNS, CKNS- Clinical Educator
