Short-term glycemic marker
Quality and Security
High-quality testing run in a CLIA-certified and CAP-accredited lab in Santa Clara, California.
About Glycated Serum Protein
${ activeTab.tab_content.text }
Loading...
About Glycated Serum Protein
Overview and History
Glycated Serum Protein belongs to the biochemical class of glycated proteins (often reported as fructosamine), formed when circulating sugars bind non-enzymatically to plasma proteins such as albumin. This glycation modifies protein structure and can alter biochemical behavior and signaling. Clinically, GSP emerged as a short-term glycemic marker useful when long-term hemoglobin-based measures are affected by blood disorders or when recent changes in glucose control need tracking. At a biological level, higher glycation burden links to increased oxidative stress and inflammatory signaling that are relevant to vascular function.
Interpreting Highs and Lows
Elevated GSP is associated with higher average glucose exposure in the preceding weeks and with an increased glycation burden that can coincide with markers of metabolic strain, inflammation, and oxidative stress. Low GSP can reflect lower recent blood-sugar exposure or reduced circulating protein levels (for example low albumin), increased protein turnover, or dilutional effects. Laboratory variability, liver or kidney disorders that change protein concentration, and concurrent markers in the Cardio Zoomer panel (HbA1c, fasting glucose, albumin, kidney and liver tests) are important when interpreting elevated or low values.
Featured Test
Cardio Zoomer includes Glycated Serum Protein to capture short-term glycemic exposure that complements HbA1c and glucose metrics. GSP helps detect recent changes in metabolic load, clarifies temporal patterns of glycemic stress, and integrates with inflammation, lipid, and endothelial markers to refine personalized cardiovascular risk mapping.
Related Articles
Cardiovascular disease remains the leading cause of death worldwide, yet most testing still focuses on surface-level metrics like total cholesterol or...
What do you think of when you hear the term “cardiovascular disease?” Most people immediately think of high cholesterol, but cardiovascular risk goes ...
A common theme among many of my nutrition clients is that despite eating well, staying active, and managing stress, they feel worn down, inflamed, and...
When it comes to cardiovascular disease (CVD), many people immediately think of high cholesterol. High cholesterol—a specific type of dyslipidemia or ...
Results trusted by over 18,000 functional wellness professionals
We’re the leading provider of specialty wellness lab testing because we develop our testing with rigorous, ongoing research by top clinical experts, doctors, and scientists.
-1.png?width=542&height=427&name=shutterstock_2371998817%201%20(1)-1.png)
.png?width=207&height=108&name=Group%201410104259%20(1).png)
The gold standard of accuracy in the lab industry
Our tests run on a proprietary 3Dense microchip technology platform that boasts unrivaled specificity and sensitivity. While most other labs carry only CLIA certification, we're CAP-accredited by the College of American Pathologists.
.png?width=487&height=356&name=Frame%201410104197%20(3).png)
.png?width=187&height=63&name=category%20Card%20text%20(1).png)
.png?width=202&height=63&name=category%20Card%20text%20(2).png)
Mary Beth Augustine
DCN, RDN, FAND- Lead Clinical Educator
Suzanne Barker
MS, RDN, LD, CTTS, CGP- Clinical Educator
Suzette Garcia
MSc- MHNE- Clinical Educator
Brooke Mader Ganev
MS, CNS, LDN, FDN- Clinical Educator
Adair Anderson
MS, RDN, LDN- Clinical Educator
Lillie Luu Nguyen
DCN, CNS, LDN- Clinical Educator
Jason Barker
ND- Clinical Educator
Emaline Brown
ND- Clinical Educator
Dana Filatova
DCN, CNS, LDN- Clinical Educator
Jessy Dhanjal
ND- Clinical Educator
Nour Amri
MS, LDN, CNS, CKNS- Clinical Educator
