GPIHBP1 encodes a glycosylphosphatidylinositol-anchored protein expressed on the endothelial surface that binds and transports lipoprotein lipase (LPL) from the interstitial space to the capillary lumen. LPL at the capillary surface breaks down triglyceride-rich lipoproteins into smaller components that tissues can take up. rs72691625 is a single-nucleotide polymorphism (SNP) within the GPIHBP1 locus that has been identified in genetic studies of lipid metabolism. Research linking GPIHBP1 variants to altered triglyceride handling and distinctive lipoprotein particle patterns has driven interest in this gene for understanding inherited contributors to lipid profiles.

Presence of the alternate allele (often described as “higher” in genetic burden) has been associated in studies with shifts in triglyceride-rich particle clearance and with changes in triglyceride and lipoprotein particle patterns. This can show up as higher concentrations of triglyceride-rich particles or altered particle size distributions on biochemical testing. Carrying the reference allele or lacking the alternate allele (often described as “lower”) is generally associated with the expected range of LPL trafficking seen in population studies. Interpretation requires the full Cardio Zoomer panel—lipids, apoB, triglycerides, and inflammatory or metabolic markers—to determine whether genetic variation meaningfully aligns with current blood measurements and clinical context.

GPIHBP1 – rs72691625 is included in Cardio Zoomer to clarify inherited influences on triglyceride handling and lipoprotein trafficking. It helps clinicians link genetic tendencies to measured lipid and particle patterns, improving interpretation of why a person’s triglycerides or lipoprotein sizes may differ from typical expectations.