What is LDLRAP1 – rs12071264 and Why Does the Cardio Zoomer Test for It?

LDL receptor adaptor variant

A single-nucleotide variant in the LDLRAP1 gene that can influence how cells clear LDL particles. LDLRAP1 encodes an adaptor protein involved in LDL receptor internalization and cellular uptake of LDL. Knowing a person’s rs12071264 genotype can help explain inherited differences in lipid patterns when combined with other Cardio Zoomer markers.

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LDLRAP1 – rs12071264

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About LDLRAP1 – rs12071264

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About LDLRAP1 – rs12071264

Overview and History

rs12071264 is a single-nucleotide polymorphism (SNP) located in the LDLRAP1 gene, a human protein-coding gene. It is a genetic marker rather than a protein or metabolite, and is reported as different base alleles (genotypes) that are analyzed in population and clinical studies. LDLRAP1 encodes an intracellular adaptor that participates in clathrin-mediated endocytosis of the LDL receptor in liver cells. Research over decades has linked rare disruptive LDLRAP1 variants to altered LDL receptor trafficking; common variants such as rs12071264 have been evaluated for association with lipid traits and cardiovascular-related patterns in cohort studies.

Interpreting Highs and Lows

Higher allele counts or genotypes associated with altered LDLRAP1 function have been linked in some studies to patterns consistent with reduced cellular LDL uptake and changes in measured LDL-related biomarkers. This may show up as higher LDL-related lab values or altered lipoprotein profiles in the full panel. Conversely, genotypes not associated with altered LDLRAP1 function suggest typical adaptor activity; in isolation this does not prove normal lipid handling. Genetic signals are probabilistic and should be interpreted alongside Cardio Zoomer’s lipid, inflammatory, metabolic, and vascular markers for a complete view.

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Cardio Zoomer includes rs12071264 to capture inherited variation that can influence LDL receptor adaptor activity and help explain why lipid measurements differ between individuals. As part of the integrated panel, this marker refines interpretation of lipid behavior and supports more personalized risk-pattern analysis for clinicians.

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LDLRAP1 – rs12071264 FAQs

What is LDLRAP1 – rs12071264 and why is it important?

rs12071264 is a genetic variant in LDLRAP1, a gene involved in moving LDL receptors into cells. It’s important because different genotypes can be linked to how efficiently LDL particles are cleared from the bloodstream, helping explain individual differences in lipid test results when seen with other markers.

What does it mean if my LDLRAP1 – rs12071264 levels are low?

For a genetic marker, “low” typically means having fewer copies of an allele that research has linked to altered function. That pattern is generally associated with a lower likelihood of measurable impact on LDL receptor adaptor activity. Interpretation depends on the rest of your Cardio Zoomer results, such as lipids and inflammation, before drawing conclusions about risk patterns.

What does it mean if my LDLRAP1 – rs12071264 levels are high?

A higher count of an allele associated with functional change may be linked in some studies to altered LDL receptor trafficking and related shifts in LDL-related lab values. This does not diagnose a condition; it signals an inherited pattern that should be evaluated together with the panel’s lipid, metabolic, and vascular markers for clinical context.

Why is this biomarker included in the Cardio Zoomer?

rs12071264 provides inherited context about LDL receptor adaptor activity that helps explain individual lipid patterns and variability. Including it lets providers integrate genetic predisposition with advanced lipid and inflammatory markers, improving pattern recognition and personalization of cardiovascular risk assessment.

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