What is NOS2 – rs1800482, rs3730017 and Why Does the Cardio Zoomer Test for It?

iNOS genetic variants

These are common genetic variants in NOS2, the gene for inducible nitric oxide synthase (iNOS). iNOS helps generate nitric oxide, a signaling molecule involved in inflammation and vascular tone; knowing NOS2 variants offers insight into inherited tendencies in nitric‑oxide–related biology that complement blood and urine markers on Cardio Zoomer.

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NOS2 – rs1800482, rs3730017

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About NOS2 – rs1800482, rs3730017

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About NOS2 – rs1800482, rs3730017

Overview and History

NOS2 encodes inducible nitric oxide synthase (iNOS), an enzyme that produces nitric oxide (NO) in immune and vascular cells. The listed entries (rs1800482 and rs3730017) are single nucleotide polymorphisms (SNPs) in regulatory regions that have been studied for effects on gene expression and enzyme activity. Research into these variants has focused on how inherited differences in NOS2 may shape inflammatory signaling, redox balance, and endothelial responses. At the biochemical level, iNOS-driven NO influences cell signaling, microbicidal activity, and vessel responsiveness through modulation of smooth muscle and oxidative pathways.

Interpreting Highs and Lows

Some alleles are associated with comparatively higher NOS2 expression or activity; this pattern can correspond with stronger inducible NO signaling, altered inflammatory signaling, and shifts in oxidative balance. Other alleles are linked to lower NOS2 expression or activity, suggesting a reduced inducible NO response under inflammatory stimulation. Genetic effects are tendencies, not fixed outcomes: interpretation is most informative when integrated with Cardio Zoomer’s inflammatory, endothelial, and oxidative stress biomarkers to reveal consistent patterns across pathways.

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Cardio Zoomer includes NOS2 variants to capture inherited influence on nitric‑oxide signaling, inflammation, and endothelial function. These genetic data help clinicians interpret biochemical markers and tailor investigative focus by revealing predispositions in NO‑related pathways that affect vascular and inflammatory patterns.

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NOS2 – rs1800482, rs3730017 FAQs

What is NOS2 – rs1800482, rs3730017 and why is it important?

These are specific genetic variants in the NOS2 gene, which controls production of inducible nitric oxide synthase (iNOS). Variants can influence how strongly iNOS is produced or activated, which in turn affects nitric‑oxide signaling tied to inflammation and vascular behavior. Knowing your NOS2 variants helps place blood and urine test results into a broader inherited context.

What does it mean if my NOS2 – rs1800482, rs3730017 levels are low?

For genetic markers, “low” typically means a genotype linked to lower NOS2 expression or inducible iNOS activity. That pattern may be associated with a weaker inducible nitric‑oxide response during inflammatory challenge and can change how inflammation and vascular markers behave. Clinical interpretation requires comparing genotype tendencies with the rest of your Cardio Zoomer panel.

What does it mean if my NOS2 – rs1800482, rs3730017 levels are high?

A genotype associated with higher NOS2 expression suggests a tendency toward stronger inducible nitric‑oxide production under inflammatory conditions. That can relate to more prominent NO‑mediated signaling, which interacts with oxidative stress and endothelial markers. Any implication depends on the total pattern of results across inflammatory, redox, and vascular tests in Cardio Zoomer.

Why is this biomarker included in the Cardio Zoomer?

NOS2 variants inform inherited tendencies in nitric‑oxide signaling, a core regulator of inflammation and vascular function. When combined with biochemical markers, these genetic insights help clarify root contributors to observed patterns and support more precise, individualized interpretation of cardiovascular‑related biology.

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