Cell-cycle regulatory variant
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About ZC3HC1 – rs11556924
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About ZC3HC1 – rs11556924
Overview and History
ZC3HC1 – rs11556924 is a single-nucleotide polymorphism (SNP) in the ZC3HC1 gene. ZC3HC1 encodes a protein involved in ubiquitin-mediated protein degradation and cell-cycle regulation, processes that influence how vascular cells grow, divide, and respond to stress.
This variant was identified through large-scale genetic association studies that searched for common variants correlated with cardiovascular traits. While it does not by itself determine health outcomes, the SNP is used as a population-level marker of inherited tendencies that can interact with lipid, inflammatory, metabolic, and vascular pathways measured elsewhere in the Cardio Zoomer panel.
Interpreting Highs and Lows
For genetic markers like rs11556924, “elevated” means carrying the allele that studies have associated with altered cardiovascular traits; “low” means carrying the alternative allele or not carrying the associated allele. Presence of the associated allele has been linked in research to measurable differences in vascular cell function and to shifts in population-level cardiovascular risk patterns. Absence of that allele suggests a smaller or different inherited contribution from this locus. Interpretation requires integration with labs, imaging, family history, and other genetic markers in the full Cardio Zoomer profile.
Featured Test
Cardio Zoomer includes ZC3HC1 – rs11556924 to capture inherited variation that can help explain why an individual’s lipid, inflammatory, or vascular markers behave as they do. As part of an array of genetic and biochemical tests, this variant helps clinicians stratify patterns of inherited risk and tailor monitoring and prevention strategies to the patient’s overall cardiovascular profile.
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Mary Beth Augustine
DCN, RDN, FAND- Lead Clinical Educator
Suzanne Barker
MS, RDN, LD, CTTS, CGP- Clinical Educator
Suzette Garcia
MSc- MHNE- Clinical Educator
Brooke Mader Ganev
MS, CNS, LDN, FDN- Clinical Educator
Adair Anderson
MS, RDN, LDN- Clinical Educator
Lillie Luu Nguyen
DCN, CNS, LDN- Clinical Educator
Jason Barker
ND- Clinical Educator
Emaline Brown
ND- Clinical Educator
Dana Filatova
DCN, CNS, LDN- Clinical Educator
Jessy Dhanjal
ND- Clinical Educator
Nour Amri
MS, LDN, CNS, CKNS- Clinical Educator
