Mansonella is a genus of parasitic filarial worms that primarily infect humans, with Mansonella ozzardi and Mansonella perstans being the most commonly studied species. First identified in the mid-20th century, these parasites are endemic to certain tropical and subtropical regions, particularly in Africa and South America. Mansonella infections are often asymptomatic, but they can lead to a range of health issues, including dermatitis, lymphadenopathy, and joint pain in some cases. The study of Mansonella has significant implications for understanding vector-borne diseases and their interactions with human health, as these parasites are transmitted by various species of biting flies. Research into Mansonella continues to evolve, focusing on its pathology, ecological interactions, and potential as a biomarker for broader health assessments in affected populations.

Elevated levels of Mansonella may indicate an active exposure to this parasitic infection, suggesting potential immune responses or inflammatory processes triggered by the pathogen. Such elevations could be associated with symptoms such as fatigue, joint pain, or skin rashes. Conversely, low levels of Mansonella may suggest either an absence of active infection or an effective immune response in clearing the parasite. This can indicate a healthier immune status or may reflect successful treatment outcomes in individuals previously affected by the parasite. However, very low levels might also indicate a lack of certain environmental exposures, which could influence overall ecosystem balance in the body.

Mansonella is an important biomarker featured in the Gut Zoomer panel, used to assess the presence of this filarial nematode associated with lymphatic inflammation and various other health challenges. By integrating Mansonella testing into the Vibrant Wellness Test, practitioners can gain insights into potential parasitic infections that may contribute to gastrointestinal and immune system dysfunctions. This valuable marker helps guide targeted interventions for improved gut health and overall wellness.