Staphylococcus epidermidis is a gram-positive bacterium that is part of the Staphylococcus genus and a prominent member of the human skin microbiome. It was first described in the late 19th century, with its identification tracing back to 1884 by the bacteriologist H. E. F. F. V. Doering. Initially considered a non-pathogenic organism, Staphylococcus epidermidis has since gained recognition for its role as an opportunistic pathogen, particularly in immunocompromised patients and those with implanted medical devices. This bacterium is well-known for its ability to form biofilms, which contribute to its persistence on both skin and implanted foreign surfaces, making it a significant focus of research in clinical microbiology. Over the years, Staphylococcus epidermidis has been increasingly utilized as a biomarker in various tests due to its association with skin health, the microbiome's stability, and its implications in healthcare-associated infections. Its history reflects the shifting understanding of microbial roles in human health and disease, highlighting the bacterium's dual identity as both a harmless commensal and a potential threat in specific clinical contexts.

Elevated Staphylococcus epidermidis levels may indicate an imbalance in skin and mucosal microbiota, potentially reflecting skin colonization or infection risk. High levels can suggest a compromised immune response or disruption in natural microbial communities, which might lead to skin irritation or diseases. Conversely, low levels may signify a healthy skin barrier and balanced microbiota, but they can also indicate an increased susceptibility to infections or failure to colonize by beneficial microbes. Maintaining optimal levels of Staphylococcus epidermidis is crucial for overall skin health and immune function.

Staphylococcus epidermidis is featured in the Gut Zoomer panel, playing a significant role in the assessment of gut microbiome health. As a coagulase-negative staphylococcus, it is normally found on the skin and mucous membranes. Its presence in the Gut Zoomer test can indicate the balance and diversity of the gut microbiota, as well as potential disruptions that may affect overall immune function and gut health. By integrating Staphylococcus epidermidis into the Vibrant Wellness Test, practitioners can gain insights into microbial dynamics, assisting in tailored interventions to optimize gut health and enhance well-being.