What is rs10741657 (CYP2R1) nd Why Does the Nutrient Zoomer Test for It?

Vitamin D 25‑hydroxylase variant

rs10741657 is a common genetic variant in the CYP2R1 gene, which encodes a liver enzyme that converts vitamin D into circulating 25‑hydroxyvitamin D. Variants at this position are linked to differences in blood 25‑hydroxyvitamin D and help explain individual variation in vitamin D status.

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rs10741657 (CYP2R1)

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About rs10741657 (CYP2R1)

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About rs10741657 (CYP2R1)

Overview and History

rs10741657 is a single nucleotide polymorphism (SNP) in the CYP2R1 gene, a member of the cytochrome P450 family involved in steroid and vitamin metabolism. This locus emerged in genome‑wide association studies as one genetic factor correlated with circulating 25‑hydroxyvitamin D concentrations across populations. Biologically, CYP2R1 encodes a hepatic 25‑hydroxylase that converts cholecalciferol and ergocalciferol into 25‑hydroxyvitamin D, the primary circulating form measured to assess vitamin D status. Variation at rs10741657 can influence enzyme expression or activity and therefore modulate how much 25‑hydroxyvitamin D is produced from dietary or sunlight‑derived precursors.

Interpreting Highs and Lows

Variants at rs10741657 that are associated with higher CYP2R1 activity tend to correlate with higher circulating 25‑hydroxyvitamin D in population studies, while variants linked to reduced activity are associated with lower circulating levels. These genetic associations are modest and do not act alone: measured 25‑hydroxyvitamin D, sun exposure, dietary intake, body composition, and other gene variants (for example GC or DHCR7) strongly influence vitamin D status. Interpreting rs10741657 requires the broader Nutrient Zoomer context—this SNP helps explain one part of vitamin D biology but should be combined with direct nutrient measurements and clinical factors to identify meaningful patterns.

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Nutrient Zoomer includes rs10741657 to capture inherited influence on vitamin D 25‑hydroxylation. This marker helps explain why individuals with similar diets or sun exposure can have different blood 25‑hydroxyvitamin D, informing interpretation of measured levels and supporting precision nutrition planning.

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rs10741657 (CYP2R1) FAQs

What is rs10741657 (CYP2R1) and why is it important?

rs10741657 is a genetic variant in the CYP2R1 gene, which plays a role in converting vitamin D precursors into the main circulating form measured in blood. It’s important because differences at this site are linked to variations in 25‑hydroxyvitamin D levels between people. Knowing this genetic tendency helps clarify why vitamin D measurements and needs can differ among individuals.

What does it mean if my rs10741657 (CYP2R1) levels are low?

If your rs10741657 genotype is associated with reduced CYP2R1 activity, it suggests a genetic tendency toward lower production of circulating 25‑hydroxyvitamin D. That association does not by itself diagnose anything—actual blood 25‑hydroxyvitamin D, sun exposure, diet, and other genes must be considered. This information helps explain one potential contributor to lower measured vitamin D.

What does it mean if my rs10741657 (CYP2R1) levels are high?

If your rs10741657 genotype is associated with higher CYP2R1 activity, it suggests a genetic tendency toward greater 25‑hydroxyvitamin D production. Such an association may help explain higher measured vitamin D in some people, but interpretation requires clinical context, direct 25‑hydroxyvitamin D results, and consideration of other lifestyle and genetic factors.

Why is this biomarker included in the Nutrient Zoomer?

Including rs10741657 helps providers link inherited vitamin D processing capacity to measured nutrient levels. It clarifies whether genetic predisposition may underlie unexpected 25‑hydroxyvitamin D results, supports pattern recognition across nutrient and metabolic markers, and refines personalized nutrition decisions.

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