What is rs1695 (GSTP1) nd Why Does the Nutrient Zoomer Test for It?

Glutathione S‑transferase variant

rs1695 is a common single‑letter change in the GSTP1 gene that can alter the GSTP1 enzyme’s ability to conjugate glutathione to reactive compounds. Knowing this variant helps explain individual differences in cellular detoxification and antioxidant handling, which can affect nutrient-related pathways.

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rs1695 (GSTP1)

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About rs1695 (GSTP1)

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About rs1695 (GSTP1)

Overview and History

rs1695 is a single nucleotide polymorphism (SNP) in the GSTP1 gene that results in an amino acid change at codon 105 (often described as Ile105Val). GSTP1 encodes glutathione S‑transferase pi, a phase II detoxification enzyme that attaches glutathione to electrophilic molecules to assist their removal. First characterized in molecular genetics studies of detox enzymes, the rs1695 variant has been studied for its effect on GSTP1 catalytic properties. The core biological role of GSTP1 is to support cellular antioxidant defenses and to help process environmental chemicals, lipid peroxides, and some drug metabolites through glutathione conjugation.

Interpreting Highs and Lows

For genetic markers like rs1695, interpretation focuses on genotype-associated activity rather than a numeric “level.” Genotypes linked to reduced GSTP1 activity may suggest lower conjugation capacity, potentially increasing reliance on glutathione and related antioxidant systems. Genotypes associated with higher GSTP1 activity imply stronger conjugation capacity and potentially different handling of electrophiles and oxidative byproducts. These patterns are not diagnostic on their own; their meaning depends on the broader Nutrient Zoomer data — including glutathione status, antioxidant biomarkers, mineral cofactors, and exposure history — to build an integrated picture of detox and redox balance.

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rs1695 is included to reveal inherited differences in glutathione‑dependent detoxification and antioxidant function. Paired with nutrient and metabolic markers, the genotype helps providers explain why two people with similar diets can show different nutrient needs or oxidative stress patterns, supporting more personalized testing and care.

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rs1695 (GSTP1) FAQs

What is rs1695 (GSTP1) and why is it important?

rs1695 is a common genetic change in the GSTP1 gene that can alter how the GSTP1 enzyme works. GSTP1 helps attach glutathione to reactive compounds so cells can clear them. Knowing whether you carry the variant helps explain individual differences in detoxification and antioxidant handling that relate to nutrient biology.

What does it mean if my rs1695 (GSTP1) levels are low?

Genetic results don’t show 'levels' the way blood tests do, but some rs1695 genotypes are linked to reduced GSTP1 activity. That pattern is associated with lower conjugation capacity and a greater dependence on glutathione and related antioxidant systems. Interpreting that association requires the full Nutrient Zoomer profile and clinical context.

What does it mean if my rs1695 (GSTP1) levels are high?

If your genotype is associated with higher GSTP1 activity, it suggests relatively stronger glutathione conjugation capacity. This may influence how your body handles certain reactive compounds and how related nutrient markers appear. Any interpretation should be made alongside other nutrient and metabolic results.

Why is rs1695 (GSTP1) included in the Nutrient Zoomer?

The rs1695 variant informs inherited differences in glutathione‑based detox and antioxidant pathways. When combined with blood nutrient and metabolic markers, it helps providers identify patterns—such as altered redox balance or increased dependence on glutathione—that support more precise, individualized testing and nutritional planning.

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