What is EPHX2 (rs751141)? And Why Does the Toxin Zoomer Test for It?

Soluble epoxide hydrolase gene variant

EPHX2 (rs751141) is a common genetic variant in the EPHX2 gene, which encodes the enzyme soluble epoxide hydrolase (sEH). sEH helps convert bioactive lipid epoxides into less active diols, so variation at this site can alter lipid signaling and inflammation-related pathways, providing insight into how someone’s biology may respond to environmental stressors.

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EPHX2 (rs751141)

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About EPHX2 (rs751141)

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About EPHX2 (rs751141)

Overview and History

EPHX2 is the gene that encodes soluble epoxide hydrolase (sEH), an enzyme in the epoxide hydrolase family that metabolizes epoxide-bearing lipids such as epoxyeicosatrienoic acids (EETs). Biochemically, sEH converts these signaling epoxides into diol forms, shifting cellular signaling related to inflammation, vascular tone, and cellular stress responses. Genetic variants in EPHX2, including rs751141, were identified in population studies exploring variation in lipid metabolism and response pathways. Research has linked EPHX2 variation to differences in enzyme activity and downstream biochemical patterns, making it a marker of how the body processes certain endogenous lipid mediators and how those pathways interact with environmental exposures.

Interpreting Highs and Lows

Changes in EPHX2 function may be inferred from genetic variants like rs751141 rather than from a simple blood level. Variants associated with higher sEH activity can correlate with faster conversion of lipid epoxides to diols, a pattern that may influence inflammatory signaling and vascular or metabolic responses. Variants linked to lower sEH activity can result in relatively higher levels of bioactive epoxides and altered signaling. These associations are context-dependent: interpreting a variant’s impact is most useful when combined with direct toxicant measurements and other detox-related genes on the Toxin Zoomer, rather than used in isolation.

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EPHX2 (rs751141) is included in the Toxin Zoomer because sEH activity shapes lipid signaling and inflammatory responses that modify how the body reacts to environmental toxicants. Assessing this variant helps clinicians place toxicant measurements into a genetic context, supporting more personalized interpretation of exposure effects and resilience.

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EPHX2 (rs751141) FAQs

What is EPHX2 (rs751141) and why is it important?

EPHX2 (rs751141) is a genetic variant in the gene for soluble epoxide hydrolase (sEH), an enzyme that alters signaling lipids in the body. Differences at this site can change how quickly certain bioactive fats are broken down, which in turn can influence inflammation-related pathways and the body’s response to environmental stressors. Knowing this variant helps clinicians interpret toxicant data alongside genetic tendencies.

What does it mean if my EPHX2 (rs751141) levels are low?

If a variant at rs751141 is associated with lower sEH activity, it suggests slower conversion of lipid epoxides to diols and relatively higher levels of those signaling epoxides. That pattern may be linked with altered inflammatory signaling or vascular responses, but its meaning depends on other genes and measured toxicant levels in the full Toxin Zoomer report.

What does it mean if my EPHX2 (rs751141) levels are high?

If a variant correlates with higher sEH activity, it suggests faster breakdown of lipid epoxides into diols, shifting the balance of lipid signaling. Such a pattern may be associated with different inflammatory or metabolic signaling profiles; clinical interpretation requires consideration of toxicant exposure data and other detoxification gene variants.

Why is this biomarker included in the Toxin Zoomer?

EPHX2 (rs751141) helps describe an individual’s lipid-signaling and inflammation-response tendencies, which interact with environmental toxicants. Including it lets providers interpret toxicant burdens alongside genetic capacity for handling bioactive lipids, improving precision in assessing exposure impact and biological balance.

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