What is Fumonisins B2 (FB2)? And Why Does the Toxin Zoomer Test for It?

Fusarium-derived sphingolipid disruptor

Fumonisins B2 (FB2) is a mycotoxin produced by Fusarium molds that can enter the body through contaminated grains. FB2 inhibits ceramide synthase and alters sphingolipid chemistry; measuring it helps detect recent exposure and informs interpretation of toxin burden alongside detox genetics.

View Toxin Zoomer

Fumonisins B2 (FB2)

Quality and Security

High-quality testing run in a CLIA-certified and CAP-accredited lab in Santa Clara, California.

fortified-health-HIPAA-compliance-pqgjtx4popoe2n0arp68hrz8h2as5rlhgng5b2srk8 1

About Fumonisins B2 (FB2)

${ activeTab.tab_content.text }

View ${ activeTab.tab_content.btn_label }

About Fumonisins B2 (FB2)

Overview and History

FB2 is a member of the fumonisin family of mycotoxins, produced primarily by Fusarium verticillioides and Fusarium proliferatum. These fungi commonly grow on maize and other cereals, and fumonisins are measured to assess dietary or environmental fungal contamination. Biochemically, FB2 acts as an inhibitor of ceramide synthase, a key enzyme in sphingolipid synthesis. By changing sphingolipid ratios and related signaling pathways, FB2 is of interest in environmental toxicology and food-safety research; while FB1 is the most studied fumonisin, FB2 contributes to the overall mycotoxin exposure profile clinicians monitor.

Interpreting Highs and Lows

Elevated urinary FB2 typically indicates recent or ongoing exposure to fumonisin-contaminated foods (often maize products) or to environmental molds. Higher levels act as a marker of increased mycotoxin burden and may reflect impacts on sphingolipid pathways; clinical interpretation should consider other mycotoxin results, exposure history, and detoxification genetics. Low or undetectable FB2 suggests little recent exposure at the time of sampling, rapid clearance, or concentrations below the test’s detection limit. Low levels do not rule out past intermittent exposures or exposure to other mycotoxins, and results are most informative when viewed with the full Toxin Zoomer profile and clinical context.

Featured Test

FB2 is included in the Toxin Zoomer to quantify fumonisin exposure as part of a broader mycotoxin panel. It helps identify grain- or mold-related exposure patterns and, when paired with detoxification genetics, clarifies whether an individual’s biology may affect clearance or sensitivity. This supports source-focused assessment and personalized interpretation of toxicant burden.

View Toxin Zoomer

Fumonisins B2 (FB2) FAQs

What is Fumonisins B2 (FB2) and why is it important?

FB2 is a fungal toxin often found in contaminated grains, especially corn. In the body it can interfere with how certain lipid molecules (sphingolipids) are produced and used. Testing for FB2 helps reveal recent exposure so clinicians can consider that exposure alongside other lab results and exposure history.

What does it mean if my Fumonisins B2 (FB2) levels are low?

Low or undetectable FB2 usually means little or no recent exposure to fumonisin-contaminated foods or molds at the time the sample was taken. It can also reflect rapid clearance or the timing of urine collection. Low FB2 does not exclude past intermittent exposure or exposure to other mycotoxins; interpretation improves when combined with the full mycotoxin profile and detox genetics.

What does it mean if my Fumonisins B2 (FB2) levels are high?

Higher FB2 levels suggest recent or greater exposure to fumonisin-contaminated grains or environmental molds and indicate an increased mycotoxin burden. Elevated results are a cue to review dietary and environmental sources and should be interpreted alongside other mycotoxin measures, exposure history, and detox-related genetic variants to understand clinical relevance.

Why is this biomarker included in the Toxin Zoomer?

Measuring FB2 helps the Toxin Zoomer detect fumonisin exposure as part of a comprehensive mycotoxin and toxicant profile. Combined with detoxification genetics and other toxin measurements, FB2 clarifies exposure patterns, contributes to overall burden assessment, and supports precision interpretation of environmental influences on health.

Browse Articles

How Mycotoxins Trigger Mast Cell Activation and Brain Inflammation

Many patients with chronic, unexplained symptoms have a history of mold exposure that’s never been fully explored. What begins as vague fatigue or hea...

Brendan Vermeire

Aug 13, 2025

Neural Health Toxins

How Toxin Exposure Impacts Your Cardiometabolic Health

A common theme among many of my nutrition clients is that despite eating well, staying active, and managing stress, they feel worn down, inflamed, and...

Leslie Weidner, RDN

Aug 13, 2025

Cardiovascular Health Toxins Longevity

Heavy Metals: Exposure, Oxidative Stress, & Disease Development

Heavy metals are found naturally on Earth in soil, rocks, bodies of water, and in trace amounts inthe atmosphere. However, human activities have alter...

Jamie Haleva

Jul 2, 2025

Toxins Longevity

The Impact of Endocrine Disruptors on Menopause: Exposure, Testing, and Solutions

By some estimates, environmental factors may be the cause of 24% of human diseases and disorders around the world, according to the Endocrine Society....

Leslie Weidner, RDN

Apr 23, 2025

Hormones Toxins

About Vibrant:

The Experts Behind  Every Test

Our team is built on collaboration across disciplines to advance the science of wellness and longevity. At Vibrant Wellness, lab scientists, technologists, clinical researchers, doctors, practitioners, longevity advisors, engineers, and regulatory experts work side by side to transform diagnostics.

By uniting diverse expertise under one mission, we pioneer precision testing that empowers providers to uncover root causes, personalize care plans, and optimize patient health outcomes. Every test we develop reflects this commitment—to push boundaries in functional medicine, deliver clear, actionable insights, and support clinicians in helping patients live healthier, longer lives.

View All Tests

Results trusted by over 18,000 functional wellness professionals

We’re the leading provider of specialty wellness lab testing because we develop our testing with rigorous, ongoing research by top clinical experts, doctors, and scientists.

The gold standard of accuracy in  the lab industry

Our tests run on a proprietary 3Dense microchip technology platform that boasts unrivaled specificity and sensitivity. While most other labs carry only CLIA certification, we're CAP-accredited by the College of American Pathologists.

Our Clinical Support Team

We understand that patient care doesn't end with diagnosis. To achieve Vibrant health, patients need clinical support and
obtainable lifestyle changes. Our clinical support team helps providers make informed treatment recommendations, resulting in  better patient outcomes.

Mary Beth Augustine

DCN, RDN, FAND- Lead Clinical Educator

Suzanne Barker

MS, RDN, LD, CTTS, CGP- Clinical Educator

Suzette Garcia

MSc- MHNE- Clinical Educator

Brooke Mader Ganev

MS, CNS, LDN, FDN- Clinical Educator

Adair Anderson

MS, RDN, LDN- Clinical Educator

Lillie Luu Nguyen

DCN, CNS, LDN- Clinical Educator

Jason Barker

ND- Clinical Educator

Emaline Brown

ND- Clinical Educator

Dana Filatova

DCN, CNS, LDN- Clinical Educator

Jessy Dhanjal

ND- Clinical Educator

Nour Amri

MS, LDN, CNS, CKNS- Clinical Educator

Ready to Elevate Your Approach to Precision Wellness?

At Vibrant Wellness, we’re redefining the future of diagnostics—making complex science clear, accessible, and actionable. Whether you're a provider advancing personalized care or a patient seeking data-driven answers, our precision testing gives you the clarity to make informed decisions. Experience the next generation of functional medicine through clinically validated insights and seamless testing solutions.

Become a Provider

Become a Patient