What is GSTP1 (rs1695, rs1138272)? And Why Does the Toxin Zoomer Test for It?

Phase II detox enzyme variant

GSTP1 encodes glutathione S-transferase Pi, an enzyme that helps attach glutathione to many foreign chemicals and products of oxidation. The two common variants listed (rs1695 and rs1138272) can change how the enzyme works, so testing them helps explain individual differences in handling environmental toxins and oxidative stress. Measuring these variants gives context for urinary toxicant results and other detox-related genetics on the Toxin Zoomer.

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GSTP1 (rs1695, rs1138272)

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About GSTP1 (rs1695, rs1138272)

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About GSTP1 (rs1695, rs1138272)

Overview and History

GSTP1 is a member of the glutathione S‑transferase (GST) family — cytosolic phase II enzymes that catalyze conjugation of glutathione to reactive electrophiles. Biochemically, GSTs increase solubility of many xenobiotics and endogenous oxidative products, aiding cellular clearance and limiting molecular damage. Common single-nucleotide variants such as rs1695 and rs1138272 have been widely studied because they can alter enzyme activity or substrate preference. These functional differences are relevant to how tissues like liver, lung, and other organs manage exposures to metals, chemicals, and oxidative byproducts.

Interpreting Highs and Lows

Interpretation focuses on functional effect rather than a blood “level.” Genotypes associated with lower GSTP1 activity may suggest reduced capacity to conjugate certain toxins and to neutralize oxidative byproducts, which can shift patterns of metabolite accumulation on the full Toxin Zoomer. Genotypes associated with higher or typical activity suggest relatively greater conjugation capacity for some substrates. Any single GSTP1 result is best interpreted alongside measured toxicant levels, other detox genes, and clinical context to understand overall detox balance.

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GSTP1 (rs1695, rs1138272) is included in the Toxin Zoomer to assess a core glutathione-dependent detox route. Knowing a person’s GSTP1 variants helps clinicians interpret urinary toxicants and other genetic markers, clarifying whether observed exposures are likely to be handled efficiently or may require closer monitoring in a personalized plan.

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GSTP1 (rs1695, rs1138272) FAQs

What is GSTP1 (rs1695, rs1138272) and why is it important?

GSTP1 codes for an enzyme that attaches glutathione to many reactive chemicals, helping neutralize and prepare them for elimination. The rs1695 and rs1138272 variants can change the enzyme’s function. Knowing these variants helps explain why two people with similar exposures may have different metabolite patterns or sensitivity to toxins.

What does it mean if my GSTP1 (rs1695, rs1138272) levels are low?

If your GSTP1-linked activity is lower (as indicated by certain genotypes), it may reflect reduced ability to conjugate specific toxins and clear some oxidative byproducts. That pattern has been associated with different metabolite profiles or greater susceptibility to cellular oxidative stress when exposures are present. Results are interpretive and should be viewed with your full toxicant panel and other genetic findings.

What does it mean if my GSTP1 (rs1695, rs1138272) levels are high?

If your GSTP1-related activity appears higher or typical, it suggests relatively greater capacity to conjugate and help clear certain substrates handled by this enzyme. Higher activity may change which metabolites appear in testing and how the body responds to specific exposures. Clinical interpretation requires the rest of the Toxin Zoomer data and patient context.

Why is GSTP1 tested in the Toxin Zoomer?

GSTP1 is a key glutathione-dependent detox enzyme that influences how many environmental chemicals and oxidative products are processed. Including its variants lets providers match measured toxicant patterns to underlying detox capacity, improving interpretation and supporting more precise, individualized assessment of exposure-response trends.

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