What is GSTP1 (rs1871042)? And Why Does the Toxin Zoomer Test for It?

Glutathione-conjugating enzyme variant

GSTP1 (rs1871042) is a common genetic variant in the GSTP1 gene, which encodes a glutathione S‑transferase involved in neutralizing reactive chemicals and supporting antioxidant defense. Knowing a person’s GSTP1 variant helps put measured toxicant levels into context by suggesting tendencies in how the body conjugates and clears certain compounds.

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GSTP1 (rs1871042)

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About GSTP1 (rs1871042)

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About GSTP1 (rs1871042)

Overview and History

GSTP1 belongs to the glutathione S‑transferase (GST) family, a group of phase II detoxification enzymes that attach glutathione to reactive molecules to aid elimination and reduce oxidative stress. GST enzymes are broadly conserved across humans and play key roles in metabolizing environmental chemicals, drug metabolites, and byproducts of cellular oxidation. The rs1871042 label refers to a specific single‑nucleotide variant within the GSTP1 locus that has been studied for its potential to alter enzyme function or expression. Research over decades has examined GST variants for their influence on biochemical handling of xenobiotics and on interindividual variability in response to environmental exposures; rs1871042 is one of several variants evaluated in that context.

Interpreting Highs and Lows

Interpretation focuses on function rather than a single “good” or “bad” value and must be integrated with toxicant measurements and clinical context. A variant associated with reduced GSTP1 activity or expression may suggest relatively slower conjugation of some electrophilic compounds and altered antioxidant balance, which can correlate with longer tissue exposure to certain reactive chemicals. Conversely, a variant linked to higher activity could indicate relatively faster conjugation and clearance of some substrates, though it may also change the mix of metabolites produced. These patterns are associations that help explain individual differences in detox capacity when viewed alongside the panel’s toxicant and exposure data.

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GSTP1 (rs1871042) is included to characterize a key phase II detox pathway that affects how many environmental compounds are processed. As part of the Toxin Zoomer’s detox genetics layer, it helps clinicians interpret urinary toxicant loads in light of likely conjugation capacity, supporting more personalized assessment of exposure patterns and resilience.

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GSTP1 (rs1871042) FAQs

What is GSTP1 (rs1871042) and why is it important?

GSTP1 (rs1871042) is a genetic variant in the gene for a glutathione S‑transferase enzyme. That enzyme helps attach glutathione to reactive chemicals so they can be eliminated and helps manage oxidative stress. Knowing this variant helps explain why two people with similar exposures can show different toxicant patterns or symptom tendencies.

What does it mean if my GSTP1 (rs1871042) levels are low?

When described as “low,” this typically refers to variants linked with reduced GSTP1 activity or expression. That pattern is associated with potentially slower conjugation and clearance of certain reactive compounds and with differences in antioxidant handling. Interpretation requires the full panel—similar toxicant measurements may have different implications depending on your genetic context.

What does it mean if my GSTP1 (rs1871042) levels are high?

When characterized as “high,” this generally means a variant associated with relatively greater GSTP1 activity or expression. That can indicate faster conjugation and removal for some substrates and a different profile of metabolites. Clinical interpretation depends on the specific toxicants measured and the rest of your detox‑genetic profile.

Why is GSTP1 (rs1871042) included in the Toxin Zoomer?

GSTP1 helps determine how the body conjugates and clears many environmental chemicals. Measuring this variant alongside urinary toxicants lets providers link exposure levels with likely biochemical handling, revealing patterns of susceptibility or resilience that support more precise, personalized interpretation of results.

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