What is ITGB3 (rs2056131)? And Why Does the Toxin Zoomer Test for It?

Platelet integrin cell receptor

ITGB3 encodes the beta‑3 subunit of integrin receptors involved in cell adhesion and platelet function. The rs2056131 variant is a common genetic difference that can influence integrin expression or activity, which in turn affects cellular adhesion, clotting-related signaling, and inflammatory responses. Measuring this variant helps place toxicant exposure findings into the context of an individual’s biological response and resilience.

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ITGB3 (rs2056131)

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About ITGB3 (rs2056131)

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About ITGB3 (rs2056131)

Overview and History

ITGB3 is the gene that encodes integrin beta‑3, a transmembrane protein that pairs with alpha subunits to form receptors involved in cell–cell and cell–matrix adhesion. Integrins are a biochemical class of adhesion receptors important for platelet aggregation, vascular integrity, and communication between cells and the extracellular matrix. Variants such as rs2056131 are single nucleotide polymorphisms (SNPs) that have been studied for how they alter integrin expression or function. Research on ITGB3 and related integrin variants has highlighted roles in platelet signaling, wound repair, and inflammatory cell trafficking, making the gene relevant to studies of vascular, immune, and tissue responses to environmental stressors.

Interpreting Highs and Lows

When literature refers to higher activity or expression linked to a particular rs2056131 allele, it may be associated with patterns of increased platelet adhesion or stronger cell–matrix signaling and related inflammatory signaling. Conversely, alleles associated with lower expression or reduced integrin activity may correspond to relatively diminished adhesion signaling or altered cell migration. Interpretation depends on the full detox/genetic profile and exposure data: a variant’s effect can be modified by other genes, current toxicant burden, medications, and clinical context, so results are best evaluated alongside the complete Toxin Zoomer report.

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ITGB3 (rs2056131) is included in the Toxin Zoomer because integrin-mediated adhesion and platelet/immune signaling shape how tissues respond to injury and toxicant exposure. The marker evaluates a genetic tendency toward altered cellular adhesion or inflammatory signaling, helping clinicians contextualize toxicant levels and personalize follow-up testing and monitoring.

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ITGB3 (rs2056131) FAQs

What is ITGB3 (rs2056131) and why is it important?

ITGB3 is the gene for the beta‑3 integrin subunit, a protein that helps cells stick together and mediates platelet signaling. rs2056131 is a common genetic variant in that gene; different alleles can influence how strongly the integrin works. Knowing your rs2056131 status gives providers additional context about how your body may respond to injury, inflammation, or environmental stresses.

What does it mean if my ITGB3 (rs2056131) levels are low?

For a genetic marker like rs2056131, “low” typically refers to an allele linked with reduced integrin expression or activity. That pattern may be associated with comparatively less platelet adhesion or altered cell migration and inflammatory signaling. Such findings are associations that gain meaning only when combined with other genetic markers, toxicant measurements, and clinical information.

What does it mean if my ITGB3 (rs2056131) levels are high?

If an allele is associated with higher integrin expression or activity, it may be linked to stronger platelet adhesion and more pronounced cell–matrix or inflammatory signaling. Elevated functional tendencies can modulate how tissues respond to toxicant exposure or injury, but the clinical significance depends on the rest of your detox/genetic profile and measured toxicant burden. Results should be interpreted in the broader context of the Toxin Zoomer panel.

Why is ITGB3 (rs2056131) included in the Toxin Zoomer?

ITGB3 informs how a person’s cells and platelets communicate during inflammation and tissue response—processes that shape reactions to toxic exposures. Including this variant helps providers detect patterns of biological sensitivity or resilience and supports more precise interpretation of toxicant results within an individualized risk and response framework.

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