What is Satratoxin H? And Why Does the Toxin Zoomer Test for It?

Macrocyclic trichothecene mycotoxin

Satratoxin H is a macrocyclic trichothecene mycotoxin produced by Stachybotrys species (black mold). It interferes with cellular protein synthesis and can influence inflammatory and immune responses. Measuring it helps indicate recent exposure to specific mold toxins and places that exposure in the context of overall toxic burden and detox capacity.

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Satratoxin H

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About Satratoxin H

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About Satratoxin H

Overview and History

Satratoxin H belongs to the macrocyclic trichothecene class of mycotoxins, a biochemical group produced by certain filamentous fungi, most notably Stachybotrys species. These compounds were characterized in toxicology and environmental medicine studies after associations were noted between water‑damaged buildings, mold growth, and clusters of symptoms in exposed populations. Biochemically, satratoxin H is a potent inhibitor of eukaryotic protein synthesis and can be cytotoxic at sufficient concentrations. It is relatively stable in the environment where mold growth occurs and can be inhaled or ingested as small particles or fragments. Analytical methods such as LC‑MS/MS can detect satratoxin H or its metabolites in biological samples to document exposure.

Interpreting Highs and Lows

Elevated urinary or environmental detection of satratoxin H typically indicates recent or ongoing exposure to Stachybotrys‑related mold sources, such as water‑damaged indoor environments or contaminated materials. Higher levels may be associated with increased inflammatory signaling or respiratory and mucosal irritation in exposed individuals, but interpretation depends on exposure route, sample timing, and individual biology. Low or undetectable levels generally suggest no recent measurable exposure, rapid clearance, or concentrations below the assay limit of detection. Results should be interpreted alongside other mycotoxin, chemical, metal, and genetic detox markers on the full Toxin Zoomer panel to form a clear exposure and response picture.

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Satratoxin H is included in the Toxin Zoomer to document exposure to Stachybotrys‑related mycotoxins and to quantify that portion of a patient’s mycotoxin load. Paired with other mold toxins and detoxification genetics, its measurement helps clinicians identify exposure patterns and align next steps with an individual’s detox capacity and symptom profile.

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Satratoxin H FAQs

What is Satratoxin H and why is it important?

Satratoxin H is a mold‑derived toxin most often linked to Stachybotrys (black mold). It can interfere with normal cell processes and is a useful marker of exposure when mold growth has occurred. Knowing whether satratoxin H is present helps clinicians understand one piece of a person’s environmental toxin profile.

What does it mean if my Satratoxin H levels are low?

Low or undetectable Satratoxin H usually means there’s no recent measurable exposure to Stachybotrys‑type molds, the body has cleared the compound, or levels are below the test’s detection limit. In some cases, sampling time, exposure route, or individual detox genetics can affect results. Interpreting low values is most meaningful when compared with the full Toxin Zoomer panel.

What does it mean if my Satratoxin H levels are high?

Higher Satratoxin H levels suggest recent or ongoing exposure to Stachybotrys‑related mold sources and raise the possibility of a greater mycotoxin burden. Elevated values can align with increased inflammatory signaling or irritation, but clinical interpretation requires review of symptoms, other mycotoxins, environmental findings, and detoxification genetics.

Why is Satratoxin H included in the Toxin Zoomer?

Measuring Satratoxin H helps identify exposure to a specific, potent mold toxin that contributes to overall mycotoxin load. When combined with other toxin measurements and detox genetics on the Toxin Zoomer, it helps clinicians detect exposure patterns, contextualize symptom associations, and personalize assessment of environmental burden and biological response.

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