What is XRCC7 (rs7003908)? And Why Does the Toxin Zoomer Test for It?

DNA double-strand break repair kinase

XRCC7 (rs7003908) is a common genetic variant in the XRCC7 gene, which encodes a kinase central to repairing DNA double‑strand breaks. Measuring this variant gives insight into individual differences in DNA‑repair tendency and how cells may respond to environmental genotoxins.

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XRCC7 (rs7003908)

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About XRCC7 (rs7003908)

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About XRCC7 (rs7003908)

Overview and History

XRCC7 (also known as PRKDC) encodes the catalytic subunit of DNA‑dependent protein kinase (DNA‑PKcs), a serine/threonine kinase essential for non‑homologous end joining (NHEJ), the main pathway for repairing DNA double‑strand breaks. rs7003908 is a single nucleotide polymorphism (SNP) in the XRCC7 locus that has been studied for its potential effects on protein function and repair efficiency. Population and laboratory studies have linked variation in XRCC7 to differences in cellular response to genotoxic stress, including ionizing radiation and chemical agents. While a single variant is not determinative, rs7003908 can provide biological context about how effectively cells detect and fix DNA damage after environmental exposures.

Interpreting Highs and Lows

For rs7003908, interpretation focuses on genotype-associated tendencies rather than concentration. Genotypes or alleles associated with reduced XRCC7 activity are linked with patterns suggesting slower or less efficient double‑strand break repair, which could mean DNA lesions persist longer after exposure to genotoxins. Genotypes associated with typical or higher XRCC7 activity suggest more effective repair responses. These patterns are probabilistic and should be interpreted alongside urinary toxicant measurements and other detoxification genes on the Toxin Zoomer.

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XRCC7 (rs7003908) is included because DNA‑repair capacity shapes how cells handle damage from metals, mold toxins, chemicals, and PFAS. Evaluating this variant helps clinicians place measured toxicant burdens into a biological context—showing whether genetic tendencies might influence persistence of cellular damage. Combined with exposure data and other detox genes, XRCC7 supports more personalized pattern-based interpretation.

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XRCC7 (rs7003908) FAQs

What is XRCC7 (rs7003908) and why is it important?

XRCC7 (rs7003908) is a genetic variant in a gene that helps cells repair breaks in DNA. It matters because environmental exposures can cause DNA damage, and repair efficiency affects how cells recover. Knowing this variant adds context to toxicant testing by suggesting a genetic tendency toward faster or slower repair.

What does it mean if my XRCC7 (rs7003908) levels are low?

For a genetic marker, “low” typically refers to an allele linked with reduced XRCC7 function. That pattern is associated with a tendency toward slower double‑strand break repair, meaning DNA damage from environmental exposures may persist longer. Genotype findings are interpreted with urinary toxicant levels, other detox genes, and clinical history.

What does it mean if my XRCC7 (rs7003908) levels are high?

An allele or genotype described as “high” generally indicates typical or increased XRCC7 activity, suggesting more effective repair of double‑strand breaks after exposure. This pattern is a genetic tendency and does not stand alone; interpretation requires the full Toxin Zoomer profile and clinical context.

Why is XRCC7 (rs7003908) included in the Toxin Zoomer?

Including XRCC7 helps place measured toxicant levels into functional context by indicating DNA‑repair tendencies. If a patient’s genetics suggest reduced repair capacity, the same toxicant burden may carry different implications than for someone with stronger repair. This integration supports precision testing by linking exposure data with biological response patterns.

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