Antioxidant Genetics

SNP Prevalence and Clinical References

This page provides prevalence data for the individual SNPs among different ethnicities along with clinical references that show the risk associations. 

A Mitochondrial Target Sequence Polymorphism in Manganese Superoxide Dismutase Predicts Inferior Survival in Breast Cancer Patients Treated with Cyclophosphamide
Genetic Polymorphisms of MnSOD Modify the Impacts of Environmental Melamine on Oxidative Stress and Early Kidney Injury in Calcium Urolithiasis Patients
Modifiable risk factors, oxidative stress markers, and SOD2 rs4880 SNP in coronary artery disease: an association study
The effect of diet on oxidative stress and metabolic diseases—Clinically controlled trials
rs366631
Population-specific GSTM1 copy number variation
The effect of diet on oxidative stress and metabolic diseases—Clinically controlled trials
rs3754446
Impact of polymorphisms in drug pathway genes on disease-free survival in adults with acute myeloid leukemia
The effect of diet on oxidative stress and metabolic diseases—Clinically controlled trials
rs7943316
The impact of catalase and glutathione peroxidase-1 genetic polymorphisms on their enzyme activities among Egyptian patients with keratoconus
Association of catalase (rs7943316) and glutathione peroxidase-1 (rs1050450) polymorphisms with the risk of type 2 diabetes (T2DM)
Antioxidant enzymes and association of CAT SNP-21 A/T (rs7943316) with male infertility
Adherence to a Dietary Approaches to Stop Hypertension (DASH)-style Diet in Relation to Preeclampsia: A Case-Control Study
rs4756146
Polymorphisms in oxidative stress genes, physical activity, and breast cancer risk
Mitochondrial Catalase and Oxidative Injury
Adherence to a Dietary Approaches to Stop Hypertension (DASH)-style Diet in Relation to Preeclampsia: A Case-Control Study
rs1001179
The association between antioxidant enzyme polymorphisms and cerebral palsy after perinatal hypoxic-ischaemic encephalopathy
Adherence to a Dietary Approaches to Stop Hypertension (DASH)-style Diet in Relation to Preeclampsia: A Case-Control Study
rs3957357
Effects of GSTA1 and GPX3 Polymorphisms on the Risk of Schizophrenia in Chinese Han Population
Selenium-Enriched Foods Are More Effective at Increasing Glutathione Peroxidase (GPx) Activity Compared with Selenomethionine: A Meta-Analysis
rs1050450
The impact of catalase and glutathione peroxidase-1 genetic polymorphisms on their enzyme activities among Egyptian patients with keratoconus
Selenium-Enriched Foods Are More Effective at Increasing Glutathione Peroxidase (GPx) Activity Compared with Selenomethionine: A Meta-Analysis
rs4902346
Genetic Variation in GPX1 Is Associated with GPX1 Activity in a Comprehensive Analysis of Genetic Variations in Selenoenzyme Genes and Their Activity and Oxidative Stress in Humans
Selenium-Enriched Foods Are More Effective at Increasing Glutathione Peroxidase (GPx) Activity Compared with Selenomethionine: A Meta-Analysis
rs2071566
Genetic Variation in GPX1 Is Associated with GPX1 Activity in a Comprehensive Analysis of Genetic Variations in Selenoenzyme Genes and Their Activity and Oxidative Stress in Humans
Selenium-Enriched Foods Are More Effective at Increasing Glutathione Peroxidase (GPx) Activity Compared with Selenomethionine: A Meta-Analysis
rs713041
Serum selenium and single-nucleotide polymorphisms in genes for selenoproteins: relationship to markers of oxidative stress in men from Auckland, New Zealand
The Role of rs713041 Glutathione Peroxidase 4 (GPX4) Single Nucleotide Polymorphism on Disease Susceptibility in Humans: A Systematic Review and Meta-Analysis
Selenium-Enriched Foods Are More Effective at Increasing Glutathione Peroxidase (GPx) Activity Compared with Selenomethionine: A Meta-Analysis
GSTP1 rs1695 and rs1871042, and SOD2 rs4880 as molecular markers of lipid peroxidation in blood storage
Relation between GSTP1 polymorphism and oxidative stress in patients with hepatocellular carcinoma
Glutathione-S-transferase (GST) P1, GSTM1, exercise, ozone and asthma incidence in school children
Selenium-Enriched Foods Are More Effective at Increasing Glutathione Peroxidase (GPx) Activity Compared with Selenomethionine: A Meta-Analysis
The GSTP1 rs1695 Polymorphism Is Associated with Mercury Levels and Neurodevelopmental Delay in Indigenous Munduruku Children from the Brazilian Amazon
rs3877899
Genetic polymorphism in selenoprotein P modifies the response to selenium-rich foods on blood levels of selenium and selenoprotein P in a randomized dietary intervention study in Danes
Food Sources of Selenium and Its Relationship with Chronic Diseases
rs1987628
Genetic Variation in GPX1 Is Associated with GPX1 Activity in a Comprehensive Analysis of Genetic Variations in Selenoenzyme Genes and Their Activity and Oxidative Stress in Humans
Selenium-Enriched Foods Are More Effective at Increasing Glutathione Peroxidase (GPx) Activity Compared with Selenomethionine: A Meta-Analysis
rs916321
Genetic variation in CYB5R3 is associated with methemoglobin levels in preterm infants receiving nitric oxide therapy
rs7310505
Polymorphisms in Thioredoxin Reductase and Selenoprotein K Genes and Selenium Status Modulate Risk of Prostate Cancer
Mutations in the mitochondrial thioredoxin reductase gene TXNRD2 cause dilated cardiomyopathy
rs2071746
Polymorphism in the HMOX1 Gene is Associated with High Levels of Fetal Hemoglobin in Brazilian Patients with Sickle Cell Anemia
rs2234694
Gene polymorphisms of superoxide dismutases and catalase in diabetes mellitus
Alterations in Concentration/Activity of Superoxide Dismutases in Context of Obesity and Selected Single Nucleotide Polymorphisms in Genes: SOD1, SOD2, SOD3
The effect of diet on oxidative stress and metabolic diseases—Clinically controlled trials
rs5746105 
Concentration/activity of superoxide dismutase isozymes and the pro-/antioxidative status, in context of type 2 diabetes and selected single nucleotide polymorphisms (genes: INS, SOD1, SOD2, SOD3) – Preliminary findings
The effect of diet on oxidative stress and metabolic diseases—Clinically controlled trials
rs1799895
Genetically Low Antioxidant Protection and Risk of Cardiovascular Disease and Heart Failure in Diabetic Subjects
Superoxide Dismutase 3 Polymorphism Associated with Reduced Lung Function in Two Large Populations
Superoxide dismutase coding of gene polymorphisms associated with susceptibility to Parkinson’s disease
The effect of diet on oxidative stress and metabolic diseases—Clinically controlled trials
rs8192287
Genetic polymorphisms of antioxidant enzymes as risk factors for oxidative stress-associated complications in preterm infants
Superoxide Dismutase 3 Polymorphism Associated with Reduced Lung Function in Two Large Populations
Polymorphisms in the Superoxide Dismutase-3 Gene Are Associated with Emphysema in COPD
The effect of diet on oxidative stress and metabolic diseases—Clinically controlled trials
rs4485648
Single nucleotide polymorphisms in the Trx2/TXNIP and TrxR2 genes of the mitochondrial thioredoxin antioxidant system and the risk of diabetic retinopathy in patients with Type 2 diabetes mellitus
Single-Nucleotide Polymorphisms in the Thioredoxin Antioxidant System and Their Association with Diabetic Nephropathy in Slovenian Patients with Type 2 Diabetes—A Preliminary Study
rs1548357
Association of thioredoxin reductase 2 (TXNRD2) gene polymorphisms with myocardial infarction in Slovene patients with type 2 diabetes mellitus
Single-Nucleotide Polymorphisms in the Thioredoxin Antioxidant System and Their Association with Diabetic Nephropathy in Slovenian Patients with Type 2 Diabetes—A Preliminary Study
rs10911021
The SNP rs10911021 is associated with oxidative stress in coronary heart disease patients from Pakistan
451-P: Association of the Genetic Variant Rs10911021 with Coronary Artery Calcium Score Is Mediated by Alterations of Glutamic Acid Metabolism in Individuals with Type 2 Diabetes
rs2796498
Effect of AMP-activated protein kinase subunit alpha 2 (PRKAA2) genetic polymorphisms on susceptibility to type 2 diabetes mellitus and diabetic nephropathy in a Chinese population
The effect of diet on oxidative stress and metabolic diseases—Clinically controlled trials
rs10789038
Effect of AMP-activated protein kinase subunit alpha 2 (PRKAA2) genetic polymorphisms on susceptibility to type 2 diabetes mellitus and diabetic nephropathy in a Chinese population
AMP-activated protein kinase: A remarkable contributor to preserve a healthy heart against ROS injury
Exercise and Type 2 Diabetes: The American College of Sports Medicine and the American Diabetes Association: joint position statement
AMP-activated protein kinase: A remarkable contributor to preserve a healthy heart against ROS injury
The effect of diet on oxidative stress and metabolic diseases—Clinically controlled trials
rs1048943
CYP1A1 and GSTs common gene variations and presbycusis risk: a genetic association analysis and a bioinformatics approach
Cohort Profile: the Predictors of Breast Cancer Recurrence (ProBe CaRE) Premenopausal Breast Cancer Cohort Study in Denmark
−337GA (rs206812)
Xanthine oxidoreductase polymorphisms: influence in blood pressure and oxidative stress levels
The effect of diet on oxidative stress and metabolic diseases—Clinically controlled trials
rs2073316 
Xanthine oxidoreductase polymorphisms: influence in blood pressure and oxidative stress levels
The effect of diet on oxidative stress and metabolic diseases—Clinically controlled trials
Association of CYBA gene (-930 A/G and 242 C/T) polymorphisms with oxidative stress in breast cancer: a case-control study
The effect of diet on oxidative stress and metabolic diseases—Clinically controlled trials
A-930G (rs9932581)
Association of CYBA gene (-930 A/G and 242 C/T) polymorphisms with oxidative stress in breast cancer: a case-control study
The effect of diet on oxidative stress and metabolic diseases—Clinically controlled trials
rs20417
Study of the relation between two common cyclooxygenase 2 gene polymorphisms with risk of developing and subtypes of vitiligo in Egyptian patients
The effect of diet on oxidative stress and metabolic diseases—Clinically controlled trials
rs8190955
Identification, analysis of deleterious SNPs of the human GSR gene and their effects on the structure and functions of associated proteins and other diseases
The effect of diet on oxidative stress and metabolic diseases—Clinically controlled trials
rs121909307
Single Nucleotide Polymorphism in Glutathione Synthetase Gene in Indian Population with Type 2 Diabetes
The effect of diet on oxidative stress and metabolic diseases—Clinically controlled trials
rs10811661
Genetic risk score of common genetic variants for impaired fasting glucose and newly diagnosed type 2 diabetes influences oxidative stress
Association of CDKN2A/B gene polymorphisms (rs10811661 and rs2383208) with type 2 diabetes mellitus in a sample of Iraqi population
The effect of diet on oxidative stress and metabolic diseases—Clinically controlled trials