Methylation Genetics

SNP Prevalence and Clinical References

This page provides prevalence data for the individual SNPs among different ethnicities along with clinical references that show the risk associations. 

Rs1801131
Association of Two Methylenetetrahydrofolate Reductase Polymorphisms (rs1801133, rs1801131) with the Risk of Type 2 Diabetes in South-East of Iran
Associations of Maternal rs1801131 Genotype in MTHFR and Serum Folate and Vitamin B12 with Gestational Diabetes Mellitus in Chinese Pregnant Women
Association analysis of MTHFR (rs1801133 and rs1801131) and MTRR (rs1801394) gene polymorphisms towards the development of hypertension in the Bai population from Yunnan, China
Warriors Versus Worriers: The Role of COMT Gene Variants
Potential Impact of COMT-rs4680 G > A Gene Polymorphism in Coronary Artery Disease
How Dietary Factors Affect DNA Methylation: Lesson from Epidemiological Studies
Rs1801394
Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome in China
How Dietary Factors Affect DNA Methylation: Lesson from Epidemiological Studies
Rs3851059
MAT1A variants are associated with hypertension, stroke, and markers of DNA damage and are modulated by plasma vitamin B-6 and folate
How Dietary Factors Affect DNA Methylation: Lesson from Epidemiological Studies
Rs1979277
Polymorphisms in serine hydroxymethyltransferase 1 and methylenetetrahydrofolate reductase interact to increase cardiovascular disease risk in humans
How Dietary Factors Affect DNA Methylation: Lesson from Epidemiological Studies
Rs10948059
Genetic polymorphisms of the glycine N-methyltransferase and prostate cancer risk in the health professionals follow-up study
How Dietary Factors Affect DNA Methylation: Lesson from Epidemiological Studies
Rs3733890
Associations of folate and choline metabolism gene polymorphisms with orofacial clefts
Association between the BHMT gene rs3733890 polymorphism and the efficacy of oral folate therapy in patients with hyperhomocysteinemia
How Dietary Factors Affect DNA Methylation: Lesson from Epidemiological Studies
rs162036
An update on vitamin B12-related gene polymorphisms and B12 status
How Dietary Factors Affect DNA Methylation: Lesson from Epidemiological Studies
rs1805087
Analysis of methionine synthase (rs1805087) gene polymorphism in autism patients in Northern Iran
Association of methionine synthase (rs1805087), methionine synthase reductase (rs1801394), and methylenetetrahydrofolate dehydrogenase 1 (rs2236225) genetic polymorphisms with recurrent implantation failure
How Dietary Factors Affect DNA Methylation: Lesson from Epidemiological Studies
COMT polymorphisms affecting protein expression are risk factors for endometrial cancer
How Dietary Factors Affect DNA Methylation: Lesson from Epidemiological Studies
rs1801133
Increased breast cancer risk at high plasma folate concentrations among women with the MT HFR 677T allele
Association analysis of MTHFR (rs1801133 and rs1801131) and MTRR (rs1801394) gene polymorphisms towards the development of hypertension in the Bai population from Yunnan, China
How Dietary Factors Affect DNA Methylation: Lesson from Epidemiological Studies
rs1799983
Glucose Tolerance, MTHFR C677T and NOS3 G894T Polymorphisms, and Global DNA Methylation in Mixed Ancestry African Individuals
Interaction between endothelial nitric oxide synthase rs1799983, cholesteryl ester-transfer protein rs708272 and angiopoietin-like protein 8 rs2278426 gene variants highly elevates the risk of type 2 diabetes mellitus and cardiovascular disease
How Dietary Factors Affect DNA Methylation: Lesson from Epidemiological Studies