Minimal Genetics

Rs1801131

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SAMe functions as a methyl donor that can help regulate homocysteine levels, indirectly supporting MTHFR activity by facilitating the conversion of homocysteine to methionine.

B Vitamins are essential cofactors for MTHFR, enhancing its activity by supporting the conversion of homocysteine to methionine and maintaining optimal enzyme function.

rs4680

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Studies show that tea catechin epigallocatechin-3-gallate (EGCG) induces the expression of COMT.

Olive oil supplements may potentially induce COMT (catechol-O-methyltransferase) expression by providing hydroxytyrosol, a polyphenol that serves as a substrate for COMT.

Red wine supplementation can potentially induce COMT expression through the presence of polyphenolic compounds like hydroxytyrosol and tyrosol, which may modulate gene expression and enzyme activity.