Cardiac rhythm-linked SNPs
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About 4q25 – rs2200733, rs10033464
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About 4q25 – rs2200733, rs10033464
Overview and History
These markers are single-nucleotide polymorphisms (SNPs) mapped to the 4q25 region of chromosome 4. They are non-coding variants identified through genome-wide association studies and are classed as common cardiogenetic risk variants rather than protein-coding mutations.
First reported in large genetic association studies, the 4q25 SNPs have been repeatedly observed to relate to differences in atrial electrical properties. Although the variants do not by themselves define a condition, they are thought to influence nearby regulatory genes involved in cardiac development and electrical signaling.
Interpreting Highs and Lows
For genetic markers like these, “elevated” means carrying one or more risk alleles and “low” means carrying none. Presence of risk alleles has been associated with a higher likelihood of developing certain patterns of atrial electrical disturbance in population studies, particularly when combined with other clinical or biochemical risk features.
Absence of risk alleles does not guarantee low overall cardiovascular risk; it simply means this specific inherited contribution is not present. Interpretation is most informative when viewed alongside Cardio Zoomer’s lipid, inflammatory, metabolic, and endothelial markers plus clinical history.
Featured Test
Cardio Zoomer includes 4q25 SNPs to capture inherited contributions to cardiac electrical behavior. These variants help clinicians contextualize why a patient may show certain rhythm tendencies and, when integrated with other domains, support more personalized monitoring and prevention strategies.
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