What is ANGPTL3 – rs1748195 and Why Does the Cardio Zoomer Test for It?

Lipid-regulating gene variant

ANGPTL3 – rs1748195 is a single-letter genetic variant in the ANGPTL3 gene, a liver-produced regulator of enzymes that affect lipid breakdown. Genotyping this variant helps reveal inherited tendencies in triglyceride and LDL particle patterns and complements blood biomarkers to clarify cardiovascular risk drivers.

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ANGPTL3 – rs1748195

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About ANGPTL3 – rs1748195

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About ANGPTL3 – rs1748195

Overview and History

ANGPTL3 – rs1748195 is a single nucleotide polymorphism (SNP) located in or near the ANGPTL3 gene, which encodes angiopoietin-like 3. ANGPTL3 is a secreted liver protein that modulates lipases involved in triglyceride and lipoprotein metabolism, affecting how the body processes circulating lipids. Genetic and population studies have linked common ANGPTL3 variants to measurable differences in blood lipid traits across groups. These associations made ANGPTL3 a focus of research into inherited contributors to lipid patterns and cardiovascular biology, and the variant is used as a genomic marker of that pathway’s influence.

Interpreting Highs and Lows

Different rs1748195 alleles have been associated with shifts in lipid-related traits in population studies: one allele is linked with patterns of higher triglycerides and certain LDL measures, while the alternate allele is associated with lower triglycerides and altered LDL characteristics. These are statistical associations, not definitive predictions — actual lipid levels reflect many factors, including other genes, diet, medications, and health conditions. Interpreting rs1748195 requires integration with measured lipids (ApoB, triglycerides, LDL particle data), inflammation markers, and clinical context provided by the full Cardio Zoomer panel.

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Cardio Zoomer includes rs1748195 to capture inherited variation in the ANGPTL3 pathway that influences lipid processing. This genetic insight helps explain why a person’s blood lipid profile may differ from expectations and assists clinicians in assembling a more complete, personalized cardiometabolic risk picture.

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ANGPTL3 – rs1748195 FAQs

What is ANGPTL3 – rs1748195 and why is it important?

It’s a common genetic variant near the ANGPTL3 gene, which helps control enzymes that process fats in the blood. Knowing your rs1748195 genotype helps explain inherited influences on triglyceride and LDL patterns and adds context to lab results when evaluating cardiovascular risk factors.

What does it mean if my ANGPTL3 – rs1748195 levels are low?

For a genetic marker like rs1748195, “low” typically refers to having the allele associated with lower ANGPTL3-related activity in population studies. That allele has been linked to lower average triglycerides and some lower LDL measures, but individual blood tests and other risk markers determine actual risk and must be reviewed together.

What does it mean if my ANGPTL3 – rs1748195 levels are high?

Having the allele linked with higher ANGPTL3-associated activity has been associated in studies with higher average triglycerides and shifts in LDL traits. This suggests an inherited tendency toward certain lipid patterns, but interpretation requires the full lab profile and clinical context to understand its relevance.

Why is this biomarker included in the Cardio Zoomer?

rs1748195 provides a genetic read on the ANGPTL3 pathway, helping to explain inherited drivers of lipid patterns that may not be apparent from blood tests alone. Combined with Cardio Zoomer’s advanced lipid, inflammatory, and metabolic markers, it sharpens the clinician’s view of what’s influencing a person’s cardiovascular risk profile.

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