What is APOA1 – rs632153, rs670 and Why Does the Cardio Zoomer Test for It?

HDL apolipoprotein gene variants

APOA1 – rs632153 and rs670 are common single-letter DNA variants in the APOA1 gene, which encodes apolipoprotein A‑I, the main protein component of HDL particles. These variants are linked in research to differences in APOA1 levels and HDL-related function, so testing them helps reveal inherited patterns that influence lipid handling and cardiovascular biology.

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APOA1 – rs632153, rs670

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About APOA1 – rs632153, rs670

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About APOA1 – rs632153, rs670

Overview and History

APOA1 is the gene that codes for apolipoprotein A‑I, a protein central to HDL particle structure and cholesterol transport processes. The entries rs632153 and rs670 are single nucleotide polymorphisms (SNPs)—single-base changes in the DNA sequence—located in or near the APOA1 gene. Scientists have studied APOA1 and promoter-region variants like rs670 for decades because changes in APOA1 expression or structure can alter HDL composition and cholesterol efflux. These SNPs are part of the genetic background that can modestly influence circulating APOA1 protein levels and lipid traits across populations; they are not diagnostic by themselves but provide inherited context for lipid biology.

Interpreting Highs and Lows

Certain alleles of these APOA1 SNPs have been associated in studies with relatively higher APOA1 protein or HDL-related measures, while other alleles have been associated with relatively lower measures. Higher inherited APOA1 tendencies may align with patterns of HDL particle composition or transport capacity; lower tendencies may align with different HDL profiles. Interpretation requires the broader Cardio Zoomer panel because the effect size of any single variant is usually modest and clinical significance depends on accompanying lipid, inflammatory, metabolic, and other genetic results.

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Cardio Zoomer includes APOA1 variants to capture inherited influences on HDL structure and cholesterol transport. These markers help clinicians place observed lipid measures into genetic context, clarifying whether lipid patterns may reflect inherited tendencies versus modifiable factors and supporting more personalized interpretation of cardiovascular risk patterns.

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APOA1 – rs632153, rs670 FAQs

What is APOA1 – rs632153, rs670 and why is it important?

These are common genetic variants in the APOA1 gene, which makes apolipoprotein A‑I, the main protein in HDL. Research links these variants to small differences in APOA1 levels and HDL-related function, so they help explain inherited patterns that affect how the body handles cholesterol.

What does it mean if my APOA1 – rs632153, rs670 levels are low?

Because these entries are genetic variants, “low” usually refers to allele patterns associated with lower APOA1 protein or weaker HDL traits in studies. That association suggests an inherited tendency toward certain HDL characteristics, but the real-world meaning depends on your actual APOA1 protein and lipid test results and the rest of your Cardio Zoomer profile.

What does it mean if my APOA1 – rs632153, rs670 levels are high?

Alleles associated with higher APOA1 or stronger HDL-related measures suggest an inherited tendency toward that pattern. Elevated genetic tendency is one piece of the picture—clinical interpretation requires your measured lipids, inflammation markers, and other genetic and metabolic information from the full panel.

Why is this biomarker included in the Cardio Zoomer?

Including APOA1 variants provides inherited context for HDL structure and cholesterol transport. When combined with direct lipid, inflammatory, and metabolic markers, these variants help clinicians distinguish genetic predisposition from acquired changes and refine personalized risk pattern assessment.

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