Apolipoprotein A-II genetic variant
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About APOA2 – rs5082
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About APOA2 – rs5082
Overview and History
rs5082 is a single‑nucleotide polymorphism (SNP) located in the regulatory region of the APOA2 gene, which encodes apolipoprotein A‑II (ApoA‑II). ApoA‑II is a small HDL-associated protein involved in HDL structure and lipid exchange, so changes in its expression can alter HDL composition and lipid transport dynamics.
Population studies first identified rs5082 as a common variant and have since examined associations with HDL metrics, triglycerides, body mass and diet interactions. Mechanistically, rs5082 is thought to affect APOA2 expression levels; this molecular effect is why the variant is of interest in studies of lipid biology and metabolic patterns rather than as a diagnostic marker.
Interpreting Highs and Lows
Some alleles at rs5082 are associated with higher ApoA‑II expression; in study populations these genotypes have been linked to altered HDL composition, modest shifts in triglyceride or HDL measurements, and stronger body‑weight or diet associations in certain groups. Other alleles are associated with lower ApoA‑II expression and often show the opposite pattern in those same associations. These are population-level associations and not determinative for any individual—interpretation is most meaningful when combined with the Cardio Zoomer lipid, inflammatory, metabolic, and clinical data.
Featured Test
APOA2 – rs5082 is included in Cardio Zoomer to provide inherited context for lipid handling and gene–diet interactions. It helps explain interindividual differences in HDL composition and metabolic patterns, so clinicians can interpret advanced lipid and metabolic markers alongside genetic tendency when forming a personalized assessment.
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Mary Beth Augustine
DCN, RDN, FAND- Lead Clinical Educator
Suzanne Barker
MS, RDN, LD, CTTS, CGP- Clinical Educator
Suzette Garcia
MSc- MHNE- Clinical Educator
Brooke Mader Ganev
MS, CNS, LDN, FDN- Clinical Educator
Adair Anderson
MS, RDN, LDN- Clinical Educator
Lillie Luu Nguyen
DCN, CNS, LDN- Clinical Educator
Jason Barker
ND- Clinical Educator
Emaline Brown
ND- Clinical Educator
Dana Filatova
DCN, CNS, LDN- Clinical Educator
Jessy Dhanjal
ND- Clinical Educator
Nour Amri
MS, LDN, CNS, CKNS- Clinical Educator
