What is AT1R – rs5182 and Why Does the Cardio Zoomer Test for It?

Angiotensin II receptor variant

AT1R – rs5182 is a common single‑nucleotide variant in the gene for the angiotensin II type 1 receptor. It relates to how angiotensin II signaling is tuned in blood vessels and kidneys, so knowing a person’s rs5182 genotype can help explain inherited patterns in vascular tone and blood‑pressure responsiveness.

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AT1R – rs5182

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About AT1R – rs5182

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About AT1R – rs5182

Overview and History

AT1R – rs5182 is a single‑nucleotide polymorphism (SNP) located in the AGTR1 gene, which encodes the angiotensin II type 1 receptor (AT1R). AT1R is a cell‑surface receptor that mediates many downstream effects of angiotensin II, including vasoconstriction, sodium handling, and cellular responses involved in vascular remodeling and inflammation. Variants of AGTR1, including rs5182, have been studied in population research for associations with blood‑pressure traits, vascular reactivity, and differences in biomarker patterns. While no single variant deterministically causes a condition, rs5182 can contribute to inherited tendencies that interact with metabolic, inflammatory, and lifestyle factors measured elsewhere on the Cardio Zoomer panel.

Interpreting Highs and Lows

Genetic results for rs5182 are reported as genotype patterns rather than concentrations. Genotypes associated with relatively higher AT1R signaling have been linked in studies to patterns such as greater vascular tone, altered salt sensitivity, or distinct blood‑pressure responses; genotypes linked with relatively lower signaling show the opposite trend. These are population‑level associations, not certainties, and their interpretation is most meaningful when combined with the Cardio Zoomer profile of lipids, inflammation, endothelial markers, and clinical history.

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Cardio Zoomer includes AT1R – rs5182 to give inherited context for vascular tone and blood‑pressure biology. This genetic marker helps explain why individuals differ in vascular reactivity, biomarker patterns, and medication response tendencies, and it refines personalized risk patterns when integrated with metabolic, lipid, and inflammatory data.

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AT1R – rs5182 FAQs

What is AT1R – rs5182 and why is it important?

AT1R – rs5182 is a common genetic variant in the angiotensin II type 1 receptor gene. That receptor helps control vascular constriction, salt handling, and signaling that affects vessel function. Knowing rs5182 genotype adds inherited context for why someone’s blood‑pressure behavior or vascular biomarker pattern might differ from others.

What does it mean if my AT1R – rs5182 levels are low?

For a genetic marker, “low” generally refers to a genotype associated with relatively lower predicted AT1R signaling or expression. That pattern may be associated with reduced angiotensin II–mediated vascular tone or different salt handling compared with genotypes linked to higher signaling. These associations are probabilistic and should be interpreted alongside the rest of your Cardio Zoomer results and clinical information.

What does it mean if my AT1R – rs5182 levels are high?

A genotype associated with higher predicted AT1R signaling may correspond with stronger angiotensin II–driven vascular responses, altered blood‑pressure patterns, or different biomarker signatures in population studies. Elevated genetic tendency does not diagnose a condition; clinical context and other biomarkers in the Cardio Zoomer panel are needed to understand its practical implications.

Why is this biomarker included in the Cardio Zoomer?

AT1R – rs5182 provides inherited insight into angiotensin II signaling and vascular tone, helping clinicians interpret blood‑pressure tendencies and vascular biomarker patterns. When combined with lipids, inflammation, endothelial and metabolic markers on Cardio Zoomer, it improves explanation of individual risk patterns and supports more tailored monitoring and prevention strategies.

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