BDKRB2 – rs1799722 is a single-nucleotide genetic variant in the BDKRB2 gene, which encodes the bradykinin B2 G-protein–coupled receptor. The B2 receptor mediates bradykinin effects on blood vessels, including vasodilation, nitric oxide release, and modulation of vascular permeability and local inflammatory signaling. Researchers have studied BDKRB2 variants for links to differences in vascular reactivity, endothelial function, and responses to hemodynamic stress. While a single variant is not determinative, rs1799722 is clinically relevant as a genetic contributor to patterns of vascular signaling that interact with metabolic, inflammatory, and lipid pathways measured in comprehensive cardiovascular panels.

Genetic variants at rs1799722 are commonly described in terms of alleles associated with relatively higher or lower receptor expression or activity. An allele linked with higher B2 receptor signaling may correspond to stronger bradykinin-driven vasodilation and altered inflammatory signaling; in isolation this can look like relatively more flexible vascular responses. An allele associated with lower receptor expression or activity may correspond to blunted bradykinin signaling, potentially reducing some vasodilatory and endothelial repair signals. Interpretation requires the broader Cardio Zoomer context: genotype effects interact with measured endothelial markers, inflammation, blood pressure patterns, and metabolic profiles. The variant is one piece of inherited biology rather than a standalone indicator of health or disease.

Cardio Zoomer includes rs1799722 to provide inherited-context on bradykinin–B2 receptor signaling and vascular responsiveness. This genetic insight helps clinicians interpret endothelial function, blood-pressure–related patterns, and inflammatory markers alongside metabolic and lipid data, supporting more personalized assessment of vascular risk drivers.