Fatty-acid transport gene variant
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About CD36 – rs1761667
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About CD36 – rs1761667
Overview and History
CD36 – rs1761667 is a single‑nucleotide polymorphism (SNP) in a regulatory region of the CD36 gene. CD36 encodes a scavenger receptor found on cells such as platelets, macrophages, adipocytes, and endothelial cells; it participates in uptake of long‑chain fatty acids and recognition of modified lipids.
This variant was identified in population studies linking genotype to differences in CD36 expression, oral fat perception, and metabolic traits. Functionally, altered CD36 expression can shift cellular fatty‑acid transport, influence how cells handle oxidized lipids, and modify platelet and immune signaling—patterns that show up in blood lipid, inflammatory, and coagulation markers.
Interpreting Highs and Lows
Interpretation of rs1761667 centers on alleles associated with relatively higher or lower CD36 expression or function. Alleles tied to higher CD36 expression may be associated with greater cellular fatty‑acid uptake, altered lipid processing, and shifts in platelet or immune responses. Alleles linked to lower CD36 expression may correspond with reduced fatty‑acid uptake, different lipid signatures, and alternative platelet or inflammatory signaling patterns.
Genetic associations are one piece of the puzzle: meaningful interpretation requires integration with the Cardio Zoomer lipid panel, inflammatory markers, platelet and endothelial measures, and clinical context to recognize coherent biological patterns rather than standalone conclusions.
Featured Test
CD36 – rs1761667 is included in Cardio Zoomer to add genetic context to lipid metabolism, platelet behavior, and inflammatory tendencies. This variant helps clinicians interpret why an individual’s laboratory pattern may deviate from expectations and supports personalized monitoring and risk-pattern recognition when combined with the panel’s biochemical markers.
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Mary Beth Augustine
DCN, RDN, FAND- Lead Clinical Educator
Suzanne Barker
MS, RDN, LD, CTTS, CGP- Clinical Educator
Suzette Garcia
MSc- MHNE- Clinical Educator
Brooke Mader Ganev
MS, CNS, LDN, FDN- Clinical Educator
Adair Anderson
MS, RDN, LDN- Clinical Educator
Lillie Luu Nguyen
DCN, CNS, LDN- Clinical Educator
Jason Barker
ND- Clinical Educator
Emaline Brown
ND- Clinical Educator
Dana Filatova
DCN, CNS, LDN- Clinical Educator
Jessy Dhanjal
ND- Clinical Educator
Nour Amri
MS, LDN, CNS, CKNS- Clinical Educator
