What is CYP11B2 – rs1799998 and Why Does the Cardio Zoomer Test for It?

Aldosterone synthase variant

CYP11B2 – rs1799998 is a common single‑nucleotide variant in the gene that encodes aldosterone synthase, an enzyme involved in aldosterone production. Variation at this site can influence adrenal hormone expression and downstream effects on salt balance and vascular tone. Knowing a person’s rs1799998 genotype helps place hormone and vascular markers into an inherited-context when interpreting cardiovascular risk patterns.

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CYP11B2 – rs1799998

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About CYP11B2 – rs1799998

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About CYP11B2 – rs1799998

Overview and History

CYP11B2 – rs1799998 is a single‑nucleotide polymorphism (SNP) in the promoter region of CYP11B2, the gene that encodes aldosterone synthase. Aldosterone synthase catalyzes the terminal steps of aldosterone biosynthesis in the adrenal cortex, a hormone important for sodium retention, potassium excretion, and blood‑volume regulation. This variant was identified in population genetic studies and has been studied for associations with differences in aldosterone levels, blood‑pressure traits, and salt sensitivity. Functionally, promoter variants like rs1799998 can alter gene expression levels rather than changing the enzyme’s amino‑acid sequence, so their effects are often described as shifts in hormone production tendency rather than absolute measures.

Interpreting Highs and Lows

Genetic testing reports alleles or genotypes for rs1799998 rather than a circulating “level.” In research, some alleles have been associated with relatively higher aldosterone synthesis or greater aldosterone responsiveness; such an association can be described as a genotype linked to increased aldosterone‑related activity. Conversely, the alternate allele has been associated with comparatively lower aldosterone expression in some studies. Interpretation of a genotype-associated increase or decrease should be done alongside measured hormone levels, blood‑pressure data, electrolyte tests, and other Cardio Zoomer markers. A genotype association is one piece of evidence about inherited tendency and does not alone determine clinical status or risk.

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CYP11B2 – rs1799998 is included in Cardio Zoomer to capture an inherited influence on aldosterone biology, salt handling, and vascular regulation. When combined with aldosterone measures, electrolytes, blood‑pressure patterns, and inflammatory or lipid markers, the genotype helps clinicians understand whether inherited aldosterone tendencies may contribute to an individual’s overall cardiovascular profile and guide targeted follow‑up testing.

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CYP11B2 – rs1799998 FAQs

What is CYP11B2 – rs1799998 and why is it important?

This marker is a common genetic variant in the promoter of the CYP11B2 gene, which controls aldosterone synthase expression. It matters because different alleles have been linked to how much aldosterone the adrenal glands tend to produce, which can influence salt balance and vascular behavior. It’s used as a genetic clue to help explain patterns seen in other cardiovascular tests.

What does it mean if my CYP11B2 – rs1799998 levels are low?

Genetic testing gives a genotype, not a circulating level. If your genotype has been linked in studies to lower aldosterone expression, it suggests a relative tendency toward lower aldosterone‑driven effects (for example, less salt retention). That association is best interpreted with measured aldosterone, electrolytes, blood pressure, and other Cardio Zoomer results.

What does it mean if my CYP11B2 – rs1799998 levels are high?

If you carry the allele that studies associate with higher aldosterone expression, that indicates a genetic tendency toward greater aldosterone activity or responsiveness. Such a pattern can be associated with salt sensitivity or different blood‑pressure responses, but clinical meaning depends on hormone measurements and the broader panel context.

Why is this biomarker included in the Cardio Zoomer?

Including rs1799998 adds inherited context about aldosterone synthesis and salt/volume physiology. Combined with hormonal, electrolyte, vascular, and lipid biomarkers in Cardio Zoomer, the genotype helps clinicians identify patterns where inherited aldosterone tendency may interact with metabolic or inflammatory drivers of cardiovascular stress.

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