What is CYP1A2 – rs762551 and Why Does the Cardio Zoomer Test for It?

Liver drug-metabolizing enzyme variant

CYP1A2 – rs762551 is a common single-letter genetic change in the CYP1A2 gene, which encodes a liver enzyme that helps break down caffeine and many small molecules. This variant is linked to differences in how strongly the enzyme can be induced and thus affects metabolic pace for certain substances, giving clinicians genetic context for metabolic and pharmacogenomic patterns.

View Cardio Zoomer

CYP1A2 – rs762551

Quality and Security

High-quality testing run in a CLIA-certified and CAP-accredited lab in Santa Clara, California.

fortified-health-HIPAA-compliance-pqgjtx4popoe2n0arp68hrz8h2as5rlhgng5b2srk8 1

About CYP1A2 – rs762551

${ activeTab.tab_content.text }

View ${ activeTab.tab_content.btn_label }

About CYP1A2 – rs762551

Overview and History

CYP1A2 – rs762551 is a single nucleotide polymorphism (SNP) in the CYP1A2 gene, part of the cytochrome P450 family of phase I metabolic enzymes produced mainly in the liver. CYP1A2 performs oxidation reactions on xenobiotics and some endogenous compounds; variation at rs762551 has been studied for its role in interindividual differences in metabolism and enzyme inducibility. Historically, rs762551 (also reported as −163C>A in some studies) was identified in research on caffeine clearance and drug metabolism. It does not cause disease by itself but helps explain why people metabolize certain substances at different rates and why environmental factors can change enzyme activity differently across people.

Interpreting Highs and Lows

Genetic patterns associated with higher CYP1A2 inducibility (often linked to the A allele at rs762551 in many studies) may indicate a tendency toward faster metabolism of CYP1A2 substrates when the enzyme is induced by drugs, smoking, or diet. In practical terms this can be seen as relatively greater enzyme activity under certain exposures. Patterns associated with lower inducibility (often linked to the C allele) may indicate relatively slower metabolism of those same substrates under induction. Interpretation requires clinical context: enzyme activity is shaped by both genotype and non‑genetic factors (medications, environment, liver function), so genotype is one piece of the Cardio Zoomer puzzle rather than a standalone result.

Featured Test

Cardio Zoomer includes CYP1A2 – rs762551 to capture inherited variation in hepatic phase I metabolism that can influence biomarker levels and how people process caffeine and some cardiovascular‑relevant drugs. This genetic context helps providers interpret metabolic patterns across the panel and supports more personalized planning and monitoring.

View Cardio Zoomer

CYP1A2 – rs762551 FAQs

What is CYP1A2 – rs762551 and why is it important?

CYP1A2 – rs762551 is a common genetic variant in the gene for a liver enzyme that metabolizes caffeine and many small molecules. It matters because the variant is linked to how strongly the enzyme can be turned on, which affects the speed of metabolism for certain substances. Knowing this helps clinicians interpret metabolic patterns and pharmacogenomic context alongside other test results.

What does it mean if my CYP1A2 – rs762551 levels are low?

For a genetic marker like rs762551, “lower” typically means a genotype associated with less inducible CYP1A2 activity (often the C allele in studies). This pattern can be associated with relatively slower metabolism of CYP1A2 substrates under inducing conditions. Clinical meaning depends on other factors—medications, lifestyle, and liver function—so the result is most informative when reviewed with the full Cardio Zoomer panel.

What does it mean if my CYP1A2 – rs762551 levels are high?

A genotype associated with higher CYP1A2 inducibility (often the A allele in many studies) suggests a tendency toward faster enzyme activity when exposed to inducers like certain drugs or environmental factors. That may influence how quickly some substances are metabolized, but interpretation requires clinical context and comparison with other biomarkers and exposures.

Why is this biomarker included in the Cardio Zoomer?

Including CYP1A2 – rs762551 gives providers inherited context for hepatic metabolism that can affect biomarker behavior and drug handling. It helps connect genetic tendencies with biochemical results across the panel, supporting more precise interpretation and individualized care planning.

Browse Articles

Introducing Cardio Zoomer + Cardio Genetics: Redefining Precision in Cardiovascular Health

Cardiovascular disease remains the leading cause of death worldwide, yet most testing still focuses on surface-level metrics like total cholesterol or...

Christopher McLaughlin

Nov 7, 2025

Cardiovascular Health Research & Innovation

Nutritional Genetics: Optimizing Diet to Reduce Cardiovascular Risk

What do you think of when you hear the term “cardiovascular disease?” Most people immediately think of high cholesterol, but cardiovascular risk goes ...

Leslie Weidner, RDN

Aug 14, 2025

Cardiovascular Health Nutrients

How Toxin Exposure Impacts Your Cardiometabolic Health

A common theme among many of my nutrition clients is that despite eating well, staying active, and managing stress, they feel worn down, inflamed, and...

Leslie Weidner, RDN

Aug 13, 2025

Cardiovascular Health Toxins Longevity

Beyond Cholesterol: Functional Nutrition for Heart Health

When it comes to cardiovascular disease (CVD), many people immediately think of high cholesterol. High cholesterol—a specific type of dyslipidemia or ...

Leslie Weidner, RDN

Jul 2, 2025

Cardiovascular Health Nutrients

About Vibrant:

The Experts Behind  Every Test

Our team is built on collaboration across disciplines to advance the science of wellness and longevity. At Vibrant Wellness, lab scientists, technologists, clinical researchers, doctors, practitioners, longevity advisors, engineers, and regulatory experts work side by side to transform diagnostics.

By uniting diverse expertise under one mission, we pioneer precision testing that empowers providers to uncover root causes, personalize care plans, and optimize patient health outcomes. Every test we develop reflects this commitment—to push boundaries in functional medicine, deliver clear, actionable insights, and support clinicians in helping patients live healthier, longer lives.

View All Tests

Results trusted by over 18,000 functional wellness professionals

We’re the leading provider of specialty wellness lab testing because we develop our testing with rigorous, ongoing research by top clinical experts, doctors, and scientists.

The gold standard of accuracy in  the lab industry

Our tests run on a proprietary 3Dense microchip technology platform that boasts unrivaled specificity and sensitivity. While most other labs carry only CLIA certification, we're CAP-accredited by the College of American Pathologists.

Our Clinical Support Team

We understand that patient care doesn't end with diagnosis. To achieve Vibrant health, patients need clinical support and
obtainable lifestyle changes. Our clinical support team helps providers make informed treatment recommendations, resulting in  better patient outcomes.

Mary Beth Augustine

DCN, RDN, FAND- Lead Clinical Educator

Suzanne Barker

MS, RDN, LD, CTTS, CGP- Clinical Educator

Suzette Garcia

MSc- MHNE- Clinical Educator

Brooke Mader Ganev

MS, CNS, LDN, FDN- Clinical Educator

Adair Anderson

MS, RDN, LDN- Clinical Educator

Lillie Luu Nguyen

DCN, CNS, LDN- Clinical Educator

Jason Barker

ND- Clinical Educator

Emaline Brown

ND- Clinical Educator

Dana Filatova

DCN, CNS, LDN- Clinical Educator

Jessy Dhanjal

ND- Clinical Educator

Nour Amri

MS, LDN, CNS, CKNS- Clinical Educator

Ready to Elevate Your Approach to Precision Wellness?

At Vibrant Wellness, we’re redefining the future of diagnostics—making complex science clear, accessible, and actionable. Whether you're a provider advancing personalized care or a patient seeking data-driven answers, our precision testing gives you the clarity to make informed decisions. Experience the next generation of functional medicine through clinically validated insights and seamless testing solutions.

Become a Provider

Become a Patient