What is CYP4A11 – rs9332982, rs1126742 and Why Does the Cardio Zoomer Test for It?

Cytochrome P450 fatty-acid variant

CYP4A11 – rs9332982 and rs1126742 are common genetic variants in the CYP4A11 gene, which encodes a cytochrome P450 enzyme that metabolizes arachidonic acid into signaling lipids. Those metabolites influence vascular tone, kidney sodium handling, and local inflammatory signaling. Testing these variants gives clinicians inherited-context for patterns seen across vascular and metabolic biomarkers.

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CYP4A11 – rs9332982, rs1126742

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About CYP4A11 – rs9332982, rs1126742

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About CYP4A11 – rs9332982, rs1126742

Overview and History

CYP4A11 is a member of the cytochrome P450 enzyme family, a group of hemoproteins that catalyze oxidation of fatty acids and xenobiotics. Biochemically, CYP4A11 performs omega-hydroxylation of arachidonic acid to produce signaling eicosanoids such as 20-HETE, which act locally on blood vessels and renal tissue. Genetic variants at rs9332982 and rs1126742 have been studied for their effects on enzyme expression or activity and for associations with vascular physiology in population studies. While not diagnostic, these variants help explain interindividual differences in how arachidonic-acid metabolites are produced and how those metabolites interact with blood vessel tone, sodium handling, and inflammation.

Interpreting Highs and Lows

Interpretation is based on variant-associated effects rather than a single measured “level.” Alleles linked to increased CYP4A11 activity or expression may be associated with higher local production of 20-HETE–type metabolites and correspondingly altered vascular reactivity or renal handling patterns. Conversely, alleles associated with reduced CYP4A11 function suggest lower production of those metabolites and a different vascular or renal signaling profile. These patterns are best interpreted alongside other Cardio Zoomer results (lipids, endothelial markers, renal markers, inflammation) and clinical data to build a cohesive picture.

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CYP4A11 variants are included in Cardio Zoomer to capture inherited influence on arachidonic-acid–derived signaling that affects vascular tone, renal sodium handling, and local inflammation. This genetic context complements circulating biomarkers of endothelial function, lipids, and oxidative stress, helping providers distinguish inherited predisposition from acquired changes and refine personalized risk patterns.

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CYP4A11 – rs9332982, rs1126742 FAQs

What is CYP4A11 – rs9332982, rs1126742 and why is it important?

These are specific genetic variants in the CYP4A11 gene, which makes an enzyme that converts fatty acids into bioactive signaling molecules. Differences in these variants can change how much of those signaling lipids are produced, and that can be associated with variation in blood-vessel behavior and kidney function. Knowing your genotype adds inherited context to other cardiovascular test results.

What does it mean if my CYP4A11 – rs9332982, rs1126742 levels are low?

For genetic markers, “low” typically refers to variants linked with reduced CYP4A11 activity or expression. Those patterns are associated with lower production of certain arachidonic-acid metabolites and may be connected to a different vascular or renal signaling profile. Interpretation depends on the broader Cardio Zoomer profile and clinical context rather than the variant alone.

What does it mean if my CYP4A11 – rs9332982, rs1126742 levels are high?

If your genotype corresponds to variants associated with higher CYP4A11 activity, it may indicate greater local production of arachidonic-acid–derived signaling lipids. That pattern has been linked in studies to altered vascular reactivity and renal handling, but its meaning varies with other biomarkers and clinical factors. Clinical context from the full panel is required to interpret any potential impact.

Why is this biomarker included in the Cardio Zoomer?

CYP4A11 variants help reveal inherited tendencies in vascular signaling and renal sodium handling that influence cardiovascular physiology. When combined with lipids, endothelial markers, inflammation, and metabolic tests, the genotype helps clinicians identify which biological pathways may be driving an individual’s risk pattern and tailor further evaluation.

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