DGAT2 - rs1944438 is a single-nucleotide polymorphism (SNP) in the DGAT2 gene, which codes for diacylglycerol O-acyltransferase 2, an endoplasmic-reticulum–associated enzyme that catalyzes the terminal acylation step forming triglycerides. Biochemically, DGAT2 activity sits at a control point between diglycerides and triglyceride storage or secretion, linking cellular lipid handling to whole-body lipid measures. This variant emerged in population genetic and metabolic studies as one of several common differences that can modify DGAT2 expression or function. Research has associated rs1944438 genotypes with modest shifts in triglyceride processing, liver fat handling, and post-meal lipid responses; as with most common variants, its effects are context-dependent and additive with other genetic and lifestyle factors.

If a genotype is associated with increased DGAT2 expression or activity, studies have found patterns such as greater triglyceride synthesis, higher postprandial triglyceride excursions, or tendencies toward increased hepatic lipid storage. Conversely, genotypes associated with lower predicted DGAT2 activity may show reduced triglyceride assembly and different circulating lipid distributions. These associations are probabilistic and modest—interpretation should always integrate lipid panels, liver and metabolic markers, body composition, and lifestyle factors from the full Cardio Zoomer profile.

Cardio Zoomer includes DGAT2 - rs1944438 to add inherited context for triglyceride metabolism. This genetic marker helps explain why individuals differ in triglyceride-related lab patterns and, when combined with lipids, liver tests, and metabolic markers, supports a more personalized interpretation of cardiovascular-related biomarker patterns.