What is GCKR – rs780094 and Why Does the Cardio Zoomer Test for It?

Glucokinase regulatory SNP

rs780094 is a common single‑letter genetic variant in GCKR, the gene for glucokinase regulatory protein. It affects how the liver modulates glucose use and lipid production, and is associated with characteristic patterns in triglycerides and fasting glucose. Measuring it helps explain inherited tendencies that influence cardiometabolic labs on the Cardio Zoomer panel.

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GCKR – rs780094

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About GCKR – rs780094

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About GCKR – rs780094

Overview and History

GCKR – rs780094 is a single nucleotide polymorphism (SNP) in the GCKR gene, which encodes the glucokinase regulatory protein primarily expressed in liver cells. This variant was identified through population genetic studies and genome-wide association scans that linked common GCKR alleles to differences in metabolic lab values. Biologically, the glucokinase regulatory protein helps control glucokinase activity, a key step in hepatic glucose phosphorylation and the balance between glycolysis and lipid synthesis. The rs780094 allele is tied to measurable shifts in metabolic outputs (for example, patterns in triglyceride and fasting glucose measures) and is therefore used as an inherited marker of metabolic handling rather than a standalone diagnostic test.

Interpreting Highs and Lows

Presence of the rs780094 allele associated with higher triglycerides often coincides with a pattern of relatively higher blood triglyceride measures and, in some cohorts, modestly lower fasting glucose values. Conversely, lacking that allele is associated with the opposite inherited influence on those same measures. These associations are population-level patterns and do not predict any single lab value for an individual. Interpretation works best within the full Cardio Zoomer profile: genetic tendency shown by rs780094 can help explain why lipids, glucose, or inflammatory markers fall where they do, but must be read alongside current blood tests, clinical history, and other biomarkers on the panel.

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Cardio Zoomer includes GCKR – rs780094 to add inherited context to lipid and glucose patterns. As a genetic marker it helps clinicians distinguish whether metabolic and lipid findings reflect an inherited tendency versus primarily acquired or lifestyle-driven factors, informing more personalized interpretation of the overall cardiovascular risk map.

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GCKR – rs780094 FAQs

What is GCKR – rs780094 and why is it important?

GCKR – rs780094 is a common genetic variant in the gene that regulates glucokinase in the liver. It is important because it is associated with consistent patterns in blood triglycerides and fasting glucose across many people. Knowing your rs780094 status can help explain inherited influences on metabolic lab results measured in Cardio Zoomer.

What does it mean if my GCKR – rs780094 levels are low?

For genetic tests there aren’t ‘levels’ in the usual sense—results report which allele(s) you carry. If you do not carry the allele linked to higher triglycerides, it means you lack that particular inherited influence on lipid and glucose patterns. That absence is only one piece of the picture and should be interpreted alongside your current labs and other Cardio Zoomer markers.

What does it mean if my GCKR – rs780094 levels are high?

A result showing the rs780094 allele associated with higher triglycerides suggests an inherited tendency toward the triglyceride–glucose pattern seen in research populations. This association does not diagnose a condition; it indicates a genetic influence that should be evaluated with the rest of your lab results, inflammation markers, and clinical context.

Why is this biomarker included in the Cardio Zoomer?

GCKR – rs780094 helps clarify inherited contributions to how the body handles glucose and lipids. Including it in Cardio Zoomer lets providers separate genetic tendencies from acquired changes, improving interpretation of metabolic and lipid patterns and supporting a more personalized risk assessment.

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