What is GPX1 – rs1050450 and Why Does the Cardio Zoomer Test for It?

Antioxidant enzyme genetic variant

GPX1 – rs1050450 is a common single‑letter change in the GPX1 gene, which encodes a selenium‑dependent enzyme that helps neutralize peroxides inside cells. Testing this variant gives insight into inherited differences in cellular antioxidant capacity and how a person may handle oxidative stress within the Cardio Zoomer profile.

View Cardio Zoomer

GPX1 – rs1050450

Quality and Security

High-quality testing run in a CLIA-certified and CAP-accredited lab in Santa Clara, California.

fortified-health-HIPAA-compliance-pqgjtx4popoe2n0arp68hrz8h2as5rlhgng5b2srk8 1

About GPX1 – rs1050450

${ activeTab.tab_content.text }

View ${ activeTab.tab_content.btn_label }

About GPX1 – rs1050450

Overview and History

GPX1 (glutathione peroxidase 1) encodes a cytosolic selenoprotein that reduces hydrogen peroxide and organic hydroperoxides using glutathione. The rs1050450 single nucleotide polymorphism produces a proline→leucine substitution near the enzyme’s active region and is one of the most commonly studied GPX1 variants. This variant was identified in population genetic screens and has been examined for effects on enzyme activity and oxidative stress markers. Findings across studies vary by population, selenium status, and environment, so rs1050450 is best viewed as a functional modulator that can interact with diet and other biomarkers rather than a standalone determinant of biology.

Interpreting Highs and Lows

Presence of the rs1050450 allele that has been linked to altered GPX1 function is sometimes associated with lower measured GPX1 activity and higher circulating markers of oxidative damage in research studies; this pattern suggests relatively reduced cellular peroxide detoxification. Conversely, genotypes linked with typical GPX1 sequence tend to align with average expected enzyme activity and lower oxidative markers in similar contexts. Interpretation depends on the whole panel: measured redox biomarkers, selenium or nutrient status, and inflammatory/metabolic markers all influence how a genotype translates to biological effect.

Featured Test

Cardio Zoomer includes GPX1 – rs1050450 to add genetic context to oxidative stress and redox pathways. The variant helps explain inter-individual differences in antioxidant capacity and, when combined with blood and urine redox markers, refines interpretation of oxidative burden and personalized risk patterns for vascular and metabolic strain.

View Cardio Zoomer

GPX1 – rs1050450 FAQs

What is GPX1 – rs1050450 and why is it important?

GPX1 – rs1050450 is a common genetic change in the gene that makes glutathione peroxidase 1, an enzyme that neutralizes peroxides inside cells. The variant can influence how well the enzyme works and is studied as a factor in individual differences in oxidative stress handling. Knowing your rs1050450 status adds genetic context to lab measures of redox balance.

What does it mean if my GPX1 – rs1050450 levels are low?

For a genetic marker, “low” typically refers to a genotype associated with reduced GPX1 activity in some studies. That pattern may be linked with higher markers of oxidative damage in research, but real-world effects depend on diet, selenium status, and other biomarkers measured in the Cardio Zoomer. A clinician will interpret genotype alongside lab results and clinical context.

What does it mean if my GPX1 – rs1050450 levels are high?

If your genotype is associated with typical or higher predicted GPX1 activity, it may align with lower oxidative stress markers in some settings. Elevated or typical activity inferred from genotype does not guarantee low oxidative damage—environmental factors and other lab findings matter. Results are most meaningful when combined with direct redox and inflammatory markers.

Why is GPX1 – rs1050450 included in the Cardio Zoomer?

This variant provides genetic information about cellular antioxidant capacity, helping clinicians connect inherited tendencies to measured oxidative stress, inflammation, and metabolic markers. Including rs1050450 improves precision interpretation of redox patterns and helps explain why individuals differ in biomarker profiles.

Browse Articles

Introducing Cardio Zoomer + Cardio Genetics: Redefining Precision in Cardiovascular Health

Cardiovascular disease remains the leading cause of death worldwide, yet most testing still focuses on surface-level metrics like total cholesterol or...

Christopher McLaughlin

Nov 7, 2025

Cardiovascular Health Research & Innovation

Nutritional Genetics: Optimizing Diet to Reduce Cardiovascular Risk

What do you think of when you hear the term “cardiovascular disease?” Most people immediately think of high cholesterol, but cardiovascular risk goes ...

Leslie Weidner, RDN

Aug 14, 2025

Cardiovascular Health Nutrients

How Toxin Exposure Impacts Your Cardiometabolic Health

A common theme among many of my nutrition clients is that despite eating well, staying active, and managing stress, they feel worn down, inflamed, and...

Leslie Weidner, RDN

Aug 13, 2025

Cardiovascular Health Toxins Longevity

Beyond Cholesterol: Functional Nutrition for Heart Health

When it comes to cardiovascular disease (CVD), many people immediately think of high cholesterol. High cholesterol—a specific type of dyslipidemia or ...

Leslie Weidner, RDN

Jul 2, 2025

Cardiovascular Health Nutrients

About Vibrant:

The Experts Behind  Every Test

Our team is built on collaboration across disciplines to advance the science of wellness and longevity. At Vibrant Wellness, lab scientists, technologists, clinical researchers, doctors, practitioners, longevity advisors, engineers, and regulatory experts work side by side to transform diagnostics.

By uniting diverse expertise under one mission, we pioneer precision testing that empowers providers to uncover root causes, personalize care plans, and optimize patient health outcomes. Every test we develop reflects this commitment—to push boundaries in functional medicine, deliver clear, actionable insights, and support clinicians in helping patients live healthier, longer lives.

View All Tests

Results trusted by over 18,000 functional wellness professionals

We’re the leading provider of specialty wellness lab testing because we develop our testing with rigorous, ongoing research by top clinical experts, doctors, and scientists.

The gold standard of accuracy in  the lab industry

Our tests run on a proprietary 3Dense microchip technology platform that boasts unrivaled specificity and sensitivity. While most other labs carry only CLIA certification, we're CAP-accredited by the College of American Pathologists.

Our Clinical Support Team

We understand that patient care doesn't end with diagnosis. To achieve Vibrant health, patients need clinical support and
obtainable lifestyle changes. Our clinical support team helps providers make informed treatment recommendations, resulting in  better patient outcomes.

Mary Beth Augustine

DCN, RDN, FAND- Lead Clinical Educator

Suzanne Barker

MS, RDN, LD, CTTS, CGP- Clinical Educator

Suzette Garcia

MSc- MHNE- Clinical Educator

Brooke Mader Ganev

MS, CNS, LDN, FDN- Clinical Educator

Adair Anderson

MS, RDN, LDN- Clinical Educator

Lillie Luu Nguyen

DCN, CNS, LDN- Clinical Educator

Jason Barker

ND- Clinical Educator

Emaline Brown

ND- Clinical Educator

Dana Filatova

DCN, CNS, LDN- Clinical Educator

Jessy Dhanjal

ND- Clinical Educator

Nour Amri

MS, LDN, CNS, CKNS- Clinical Educator

Ready to Elevate Your Approach to Precision Wellness?

At Vibrant Wellness, we’re redefining the future of diagnostics—making complex science clear, accessible, and actionable. Whether you're a provider advancing personalized care or a patient seeking data-driven answers, our precision testing gives you the clarity to make informed decisions. Experience the next generation of functional medicine through clinically validated insights and seamless testing solutions.

Become a Provider

Become a Patient