What is HO1 – rs2071746 and Why Does the Cardio Zoomer Test for It?

Heme oxygenase-1 promoter variant

HO1 – rs2071746 is a common single-nucleotide variant near the HMOX1 gene that influences how the HO‑1 enzyme is regulated. HO‑1 helps break down heme and supports antioxidant, anti‑inflammatory, and vascular signaling pathways; knowing this variant gives insight into inherited differences in those protective responses.

View Cardio Zoomer

HO1 – rs2071746

Quality and Security

High-quality testing run in a CLIA-certified and CAP-accredited lab in Santa Clara, California.

fortified-health-HIPAA-compliance-pqgjtx4popoe2n0arp68hrz8h2as5rlhgng5b2srk8 1

About HO1 – rs2071746

${ activeTab.tab_content.text }

View ${ activeTab.tab_content.btn_label }

About HO1 – rs2071746

Overview and History

HO1 – rs2071746 is a single-nucleotide polymorphism located in the promoter region of the HMOX1 gene, which encodes heme oxygenase‑1 (HO‑1). As a promoter variant, rs2071746 can affect how strongly the gene is turned on in response to cellular stress, and it has been studied as a modifier of HO‑1 expression across populations. Biochemically, HO‑1 is an inducible enzyme that degrades heme into biliverdin, carbon monoxide, and free iron. These products and the enzyme’s activity are linked to antioxidant defenses, modulation of inflammation, and regulation of vascular tone. Research into HMOX1 promoter variants, including rs2071746, began in candidate‑gene studies exploring variability in stress responses and vascular outcomes.

Interpreting Highs and Lows

When a genotype is linked to higher predicted HO‑1 expression, it may be associated with a stronger inducible antioxidant and cytoprotective response under stress; in panel context this can align with lower oxidative stress markers and more favorable endothelial signals. Conversely, genotypes associated with lower predicted HO‑1 inducibility may point to a reduced capacity to clear heme and blunt antioxidant signaling, which can appear alongside higher oxidative or inflammatory markers. Interpretation requires the full Cardio Zoomer profile: genetic prediction is one piece of the puzzle and should be read together with measured redox markers, inflammatory tests, and vascular function indicators to reveal meaningful patterns.

Featured Test

Cardio Zoomer includes HO1 – rs2071746 to capture inherited variation in the body’s heme‑handling and antioxidant response. This marker helps contextualize oxidative stress and vascular signaling measured elsewhere on the panel, improving pattern recognition and supporting personalized risk interpretation by clinicians.

View Cardio Zoomer

HO1 – rs2071746 FAQs

What is HO1 – rs2071746 and why is it important?

HO1 – rs2071746 is a genetic variant near the HMOX1 gene that can influence how much HO‑1 the body makes when stressed. HO‑1 helps manage heme breakdown and supports antioxidant and vascular signaling. Knowing this variant provides one inherited piece of information about how a person’s tissues may respond to oxidative or vascular stress.

What does it mean if my HO1 – rs2071746 levels are low?

For a genetic test, “low” refers to a genotype associated with lower predicted HO‑1 inducibility. That pattern may suggest a reduced capacity for HO‑1–mediated antioxidant and heme‑clearing activity, which can show up alongside higher oxidative or inflammatory markers. Clinical interpretation depends on the Cardio Zoomer results and other measured biomarkers.

What does it mean if my HO1 – rs2071746 levels are high?

A genotype associated with higher predicted HO‑1 expression may indicate stronger inducible antioxidant and cytoprotective signaling in response to stress. That pattern can correspond with lower oxidative stress measurements or more favorable vascular markers, but the meaning depends on the broader test profile and personal clinical context.

Why is this biomarker included in the Cardio Zoomer?

HO1 – rs2071746 adds inherited context about the body’s antioxidant and heme‑handling capacity, helping clinicians interpret oxidative stress, inflammation, and endothelial markers on the panel. Combined with metabolic, lipid, and vascular data, it refines pattern recognition and supports more personalized cardiovascular risk assessment.

Browse Articles

Introducing Cardio Zoomer + Cardio Genetics: Redefining Precision in Cardiovascular Health

Cardiovascular disease remains the leading cause of death worldwide, yet most testing still focuses on surface-level metrics like total cholesterol or...

Christopher McLaughlin

Nov 7, 2025

Cardiovascular Health Research & Innovation

Nutritional Genetics: Optimizing Diet to Reduce Cardiovascular Risk

What do you think of when you hear the term “cardiovascular disease?” Most people immediately think of high cholesterol, but cardiovascular risk goes ...

Leslie Weidner, RDN

Aug 14, 2025

Cardiovascular Health Nutrients

How Toxin Exposure Impacts Your Cardiometabolic Health

A common theme among many of my nutrition clients is that despite eating well, staying active, and managing stress, they feel worn down, inflamed, and...

Leslie Weidner, RDN

Aug 13, 2025

Cardiovascular Health Toxins Longevity

Beyond Cholesterol: Functional Nutrition for Heart Health

When it comes to cardiovascular disease (CVD), many people immediately think of high cholesterol. High cholesterol—a specific type of dyslipidemia or ...

Leslie Weidner, RDN

Jul 2, 2025

Cardiovascular Health Nutrients

About Vibrant:

The Experts Behind  Every Test

Our team is built on collaboration across disciplines to advance the science of wellness and longevity. At Vibrant Wellness, lab scientists, technologists, clinical researchers, doctors, practitioners, longevity advisors, engineers, and regulatory experts work side by side to transform diagnostics.

By uniting diverse expertise under one mission, we pioneer precision testing that empowers providers to uncover root causes, personalize care plans, and optimize patient health outcomes. Every test we develop reflects this commitment—to push boundaries in functional medicine, deliver clear, actionable insights, and support clinicians in helping patients live healthier, longer lives.

View All Tests

Results trusted by over 18,000 functional wellness professionals

We’re the leading provider of specialty wellness lab testing because we develop our testing with rigorous, ongoing research by top clinical experts, doctors, and scientists.

The gold standard of accuracy in  the lab industry

Our tests run on a proprietary 3Dense microchip technology platform that boasts unrivaled specificity and sensitivity. While most other labs carry only CLIA certification, we're CAP-accredited by the College of American Pathologists.

Our Clinical Support Team

We understand that patient care doesn't end with diagnosis. To achieve Vibrant health, patients need clinical support and
obtainable lifestyle changes. Our clinical support team helps providers make informed treatment recommendations, resulting in  better patient outcomes.

Mary Beth Augustine

DCN, RDN, FAND- Lead Clinical Educator

Suzanne Barker

MS, RDN, LD, CTTS, CGP- Clinical Educator

Suzette Garcia

MSc- MHNE- Clinical Educator

Brooke Mader Ganev

MS, CNS, LDN, FDN- Clinical Educator

Adair Anderson

MS, RDN, LDN- Clinical Educator

Lillie Luu Nguyen

DCN, CNS, LDN- Clinical Educator

Jason Barker

ND- Clinical Educator

Emaline Brown

ND- Clinical Educator

Dana Filatova

DCN, CNS, LDN- Clinical Educator

Jessy Dhanjal

ND- Clinical Educator

Nour Amri

MS, LDN, CNS, CKNS- Clinical Educator

Ready to Elevate Your Approach to Precision Wellness?

At Vibrant Wellness, we’re redefining the future of diagnostics—making complex science clear, accessible, and actionable. Whether you're a provider advancing personalized care or a patient seeking data-driven answers, our precision testing gives you the clarity to make informed decisions. Experience the next generation of functional medicine through clinically validated insights and seamless testing solutions.

Become a Provider

Become a Patient