IL-6 receptor variant
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About ILR-6 – rs4845625
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About ILR-6 – rs4845625
Overview and History
rs4845625 is a single nucleotide polymorphism (SNP) located near or within the IL6R (interleukin‑6 receptor) gene. It is classified as a common genetic variant identified in population and genome‑wide association studies that associated it with variation in inflammatory biomarkers and immune signaling.
Biologically, IL6R encodes the receptor that mediates IL‑6 signaling via both membrane‑bound and soluble receptor forms. Variants in this region, including rs4845625, are thought to influence receptor expression, shedding, or splicing, which can alter downstream IL‑6 pathway activity and thereby affect patterns of systemic inflammation and vascular biology.
Interpreting Highs and Lows
Genetic patterns at rs4845625 that associate with increased IL‑6 receptor expression or signaling tend to correlate with higher circulating inflammatory markers (for example, elevated CRP) and a stronger IL‑6–mediated immune response. Conversely, patterns associated with reduced signaling tend to correlate with lower inflammatory marker levels or a blunted IL‑6 response. Interpretation should rely on the full Cardio Zoomer profile—genetic associations are one piece of evidence alongside measured blood markers, lipids, endothelial and oxidative stress indicators, and clinical context.
Featured Test
Cardio Zoomer includes rs4845625 to give genetic context to measured inflammation and cardiovascular biomarkers. The variant helps explain why individuals with similar lab values may show different inflammatory activity and supports more precise interpretation of the panel’s integrated cardiovascular risk signals.
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Mary Beth Augustine
DCN, RDN, FAND- Lead Clinical Educator
Suzanne Barker
MS, RDN, LD, CTTS, CGP- Clinical Educator
Suzette Garcia
MSc- MHNE- Clinical Educator
Brooke Mader Ganev
MS, CNS, LDN, FDN- Clinical Educator
Adair Anderson
MS, RDN, LDN- Clinical Educator
Lillie Luu Nguyen
DCN, CNS, LDN- Clinical Educator
Jason Barker
ND- Clinical Educator
Emaline Brown
ND- Clinical Educator
Dana Filatova
DCN, CNS, LDN- Clinical Educator
Jessy Dhanjal
ND- Clinical Educator
Nour Amri
MS, LDN, CNS, CKNS- Clinical Educator
