Potassium channel variant
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About KCNE2 – rs9982601
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About KCNE2 – rs9982601
Overview and History
KCNE2 – rs9982601 is a single nucleotide polymorphism (SNP) located in or near the KCNE2 gene, which encodes a small regulatory subunit for cardiac potassium channels (often called MiRP1). These subunits modulate ion flow that contributes to cardiac repolarization and the timing of the heartbeat at the cellular level.
This variant was identified through population genetic studies that look for common DNA differences tied to cardiovascular traits. As a common variant, rs9982601 does not diagnose a condition but can help explain inherited variation in electrical properties of the heart and related population-level patterns seen in large studies.
Interpreting Highs and Lows
For a genetic marker like rs9982601, “higher” or “lower” reflects how many copies of a particular allele a person carries. Carrying one or two copies of an allele that has been associated in studies with altered KCNE2 activity may be linked to subtle shifts in cardiac electrical measures or other cardiovascular traits at the population level. Having zero copies (not carrying the allele) generally indicates a background genetic profile similar to the study reference group.
Interpretation depends on the full Cardio Zoomer profile: the variant’s contribution to clinical interpretation is modest on its own and is most informative when considered alongside biomarkers of lipids, inflammation, metabolism, endothelial function, and clinical history.
Featured Test
This variant is included in Cardio Zoomer to add inherited context for cardiac electrophysiology and broader cardiovascular patterns. It helps clinicians see whether common genetic variation may partly explain individual differences in electrical markers or interact with other measured pathways, supporting more personalized interpretation of test results.
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Mary Beth Augustine
DCN, RDN, FAND- Lead Clinical Educator
Suzanne Barker
MS, RDN, LD, CTTS, CGP- Clinical Educator
Suzette Garcia
MSc- MHNE- Clinical Educator
Brooke Mader Ganev
MS, CNS, LDN, FDN- Clinical Educator
Adair Anderson
MS, RDN, LDN- Clinical Educator
Lillie Luu Nguyen
DCN, CNS, LDN- Clinical Educator
Jason Barker
ND- Clinical Educator
Emaline Brown
ND- Clinical Educator
Dana Filatova
DCN, CNS, LDN- Clinical Educator
Jessy Dhanjal
ND- Clinical Educator
Nour Amri
MS, LDN, CNS, CKNS- Clinical Educator
