Two-pore K+ channel variant
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About KCNK5 – rs10947789
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About KCNK5 – rs10947789
Overview and History
KCNK5 – rs10947789 is a single nucleotide polymorphism (SNP) located in the KCNK5 gene, part of the two‑pore domain potassium (K2P) channel family. These channels generate background potassium currents that help stabilize resting membrane potential and influence cell excitability.
KCNK5 (also called TASK‑2) is expressed in tissues such as vascular smooth muscle, endothelium, and kidney tubular cells. Genetic and physiological studies have linked variants in KCNK5 to modest differences in ion transport and related physiological traits, making this SNP of interest in population-level cardiovascular and renal research.
Interpreting Highs and Lows
High' or 'low' for rs10947789 refers to the presence or dosage of the variant allele rather than a circulating concentration. Greater allele dosage has been associated in research with subtle shifts in TASK‑2 channel behavior that can correlate with patterns in vascular tone, blood pressure regulation, or renal electrolyte handling. Absence or lower allele dosage suggests this specific variant is less likely to contribute to inherited influence on those pathways. These associations are modest; interpretation should always integrate Cardio Zoomer's biochemical, functional, and clinical markers for a full view.
Featured Test
Cardio Zoomer includes rs10947789 to capture inherited variation in ion-channel pathways that affect vascular tone and renal electrolyte balance. The genotype helps contextualize patterns seen in blood pressure, electrolyte markers, and vascular-function tests, allowing clinicians to consider a heritable component when integrating the full panel for personalized cardiovascular assessment.
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Mary Beth Augustine
DCN, RDN, FAND- Lead Clinical Educator
Suzanne Barker
MS, RDN, LD, CTTS, CGP- Clinical Educator
Suzette Garcia
MSc- MHNE- Clinical Educator
Brooke Mader Ganev
MS, CNS, LDN, FDN- Clinical Educator
Adair Anderson
MS, RDN, LDN- Clinical Educator
Lillie Luu Nguyen
DCN, CNS, LDN- Clinical Educator
Jason Barker
ND- Clinical Educator
Emaline Brown
ND- Clinical Educator
Dana Filatova
DCN, CNS, LDN- Clinical Educator
Jessy Dhanjal
ND- Clinical Educator
Nour Amri
MS, LDN, CNS, CKNS- Clinical Educator
