What is LPA – rs10455872, rs3798221, rs6415084, rs7770628, rs3798220 and Why Does the Cardio Zoomer Test for It?

Apolipoprotein(a) genetic variants

These are common single‑letter changes (SNPs) in the LPA gene that influence levels of lipoprotein(a), a cholesterol‑carrying particle containing apolipoprotein(a). Testing these variants helps explain inherited tendencies for higher or lower Lp(a) and adds genetic context to other cardiovascular markers.

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LPA – rs10455872, rs3798221, rs6415084, rs7770628, rs3798220

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About LPA – rs10455872, rs3798221, rs6415084, rs7770628, rs3798220

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About LPA – rs10455872, rs3798221, rs6415084, rs7770628, rs3798220

Overview and History

The listed markers are single‑nucleotide polymorphisms (SNPs) in the LPA gene, which encodes apolipoprotein(a). Apolipoprotein(a) binds to an LDL‑like particle to form lipoprotein(a) or Lp(a); variation in the LPA sequence alters apo(a) size and the amount of Lp(a) in blood. Variants such as rs10455872 and rs3798220 were identified in population and genome‑wide association studies as strong genetic influences on circulating Lp(a). Because Lp(a) concentrations are largely genetically determined, LPA SNPs explain much of the individual variation in Lp(a) and help interpret why some people have persistently different levels despite similar lifestyle factors.

Interpreting Highs and Lows

Carrying alleles linked to these LPA variants is associated with higher circulating Lp(a) concentrations; in research studies those higher concentrations correlate with patterns of lipid, clotting, and vascular biomarkers. Conversely, genotypes not linked to those alleles are generally associated with lower Lp(a) levels. Genetic results should be interpreted alongside measured Lp(a) concentration and the broader Cardio Zoomer profile, since non‑genetic factors and other biomarkers influence overall cardiovascular context.

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Cardio Zoomer includes LPA SNPs to provide inherited context for measured Lp(a) and to help explain persistent high or low Lp(a) that may not track with standard lipids. Integrating these variants with lipid, inflammation, and clotting markers improves interpretation and supports personalized assessment of cardiovascular biology.

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LPA – rs10455872, rs3798221, rs6415084, rs7770628, rs3798220 FAQs

What is LPA – rs10455872, rs3798221, rs6415084, rs7770628, rs3798220 and why is it important?

These are specific genetic variants in the LPA gene that influence how much lipoprotein(a) circulates in your blood. Because Lp(a) levels are strongly inherited, these SNPs help explain differences between people that aren’t explained by diet or lifestyle. Knowing your LPA variant profile adds genetic context to other lipid and clotting tests and helps clinicians interpret long‑term cardiovascular patterns.

What does it mean if my LPA – rs10455872, rs3798221, rs6415084, rs7770628, rs3798220 levels are low?

If your LPA genotype is associated with lower Lp(a), it suggests a lower inherited tendency to have high circulating Lp(a) concentrations. Low genetic predisposition typically aligns with lower measured Lp(a), but measured values and other markers still matter. Your results are most informative when considered with the full Cardio Zoomer panel and clinical history.

What does it mean if my LPA – rs10455872, rs3798221, rs6415084, rs7770628, rs3798220 levels are high?

If you carry alleles tied to higher Lp(a), that indicates an inherited tendency toward higher circulating Lp(a) concentrations. In population studies those higher concentrations are associated with distinct lipid, clotting, and vascular biomarker patterns. Elevated genetic propensity should be interpreted alongside measured Lp(a) and the rest of the Cardio Zoomer results for full clinical context.

Why is this biomarker included in the Cardio Zoomer?

LPA variants give inherited context for measured Lp(a), helping clinicians understand persistent lipid patterns that aren’t explained by lifestyle. Combined with inflammation, clotting, and lipid subfraction data, the genetic information refines the biological picture and supports more precise interpretation of cardiovascular profiles.

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