Lipoprotein lipase gene variants
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About LPL – rs328, rs7007797, rs264, rs320
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About LPL – rs328, rs7007797, rs264, rs320
Overview and History
LPL (lipoprotein lipase) is an enzyme produced in tissues like fat and muscle that breaks down triglycerides carried in chylomicrons and very-low-density lipoproteins. The listed markers (rs328, rs7007797, rs264, rs320) are single-nucleotide polymorphisms—common sequence variants in the LPL gene—that have been studied for their effects on enzyme function and circulating lipid measures.
Research over decades has linked specific LPL variants to measurable differences in triglyceride levels, HDL patterns, and lipid particle behavior. These are not diagnostic changes but are clinically relevant because they provide a genetic layer of information about lipid metabolism that complements biochemical testing.
Interpreting Highs and Lows
Different LPL variants are associated with patterns that suggest relatively higher or lower LPL activity. Genotypes linked with higher predicted activity tend to associate with lower fasting triglycerides and shifts in HDL or particle distribution, while genotypes associated with reduced activity often correlate with higher triglyceride levels and altered lipid profiles. Interpretation should focus on associations and patterns rather than absolute conclusions, and these genetic findings are most useful when integrated with the Cardio Zoomer’s biochemical lipid, inflammatory, and metabolic markers.
Featured Test
Cardio Zoomer includes these LPL variants to provide inherited context for triglyceride handling and lipid behavior. Knowing a patient’s LPL genotype helps clinicians distinguish whether unusual lipid patterns reflect inherited enzyme differences versus modifiable metabolic or inflammatory drivers, informing more precise interpretation of the overall cardiovascular risk map.
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Mary Beth Augustine
DCN, RDN, FAND- Lead Clinical Educator
Suzanne Barker
MS, RDN, LD, CTTS, CGP- Clinical Educator
Suzette Garcia
MSc- MHNE- Clinical Educator
Brooke Mader Ganev
MS, CNS, LDN, FDN- Clinical Educator
Adair Anderson
MS, RDN, LDN- Clinical Educator
Lillie Luu Nguyen
DCN, CNS, LDN- Clinical Educator
Jason Barker
ND- Clinical Educator
Emaline Brown
ND- Clinical Educator
Dana Filatova
DCN, CNS, LDN- Clinical Educator
Jessy Dhanjal
ND- Clinical Educator
Nour Amri
MS, LDN, CNS, CKNS- Clinical Educator
