What is MPO – rs2107545 and Why Does the Cardio Zoomer Test for It?

Neutrophil oxidative enzyme variant

MPO – rs2107545 is a common single nucleotide variant in the MPO (myeloperoxidase) gene. MPO is an enzyme made by neutrophils and monocytes that produces reactive oxidants used in immune defense; genetic variation can influence how much MPO is produced or how it behaves, offering insight into inherited tendencies for oxidative and inflammatory activity relevant to cardiovascular processes.

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MPO – rs2107545

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About MPO – rs2107545

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About MPO – rs2107545

Overview and History

MPO – rs2107545 is a single nucleotide polymorphism (SNP) located within or near the MPO gene, which encodes the heme-containing enzyme myeloperoxidase. MPO is a biochemical oxidase expressed primarily in neutrophils and monocytes and is involved in generating hypochlorous acid and other reactive species during innate immune responses. MPO has been studied for decades as a mediator of inflammatory and oxidative chemistry that can modify lipids, proteins, and vascular components. Variants such as rs2107545 have been identified in genetic association studies as contributors to inter-individual differences in MPO expression or activity and are used to provide inherited context for biomarker patterns.

Interpreting Highs and Lows

Alleles linked to higher MPO expression or activity are associated with greater potential for MPO-driven oxidative modification and inflammatory signaling; in biomarker panels these alleles may align with higher MPO protein, oxidized lipids, or inflammatory markers. Alleles associated with lower MPO expression or activity suggest comparatively less MPO-mediated oxidation. Neither allele status nor MPO levels alone determine clinical risk; interpretation is most informative when combined with circulating MPO protein, inflammatory markers, lipid oxidation measures, and overall clinical context.

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Cardio Zoomer includes MPO – rs2107545 to capture an inherited component of oxidative and inflammatory biology. This variant helps explain why some people show higher or lower MPO activity or related biomarker patterns, adding genetic context that complements blood and urine measures to guide more personalized risk interpretation.

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MPO – rs2107545 FAQs

What is MPO – rs2107545 and why is it important?

MPO – rs2107545 is a common genetic variant in the gene that encodes myeloperoxidase, an enzyme involved in immune-driven oxidation. The variant can be associated with differences in how much MPO is produced or how active it is. Knowing this variant helps explain inherited tendencies for MPO-linked oxidative and inflammatory patterns seen on lab testing.

What does it mean if my MPO – rs2107545 levels are low?

If you have an allele associated with lower MPO expression or activity, it may correspond with reduced MPO-related oxidation on other lab measures. Low genetic-associated activity does not imply absence of inflammation; it simply suggests a smaller inherited contribution from MPO to oxidative processes. Results are most informative when viewed alongside circulating MPO, inflammatory markers, and clinical factors.

What does it mean if my MPO – rs2107545 levels are high?

An allele associated with higher MPO expression or activity may indicate a greater inherited tendency for MPO-driven oxidative chemistry and inflammatory signaling. This pattern can align with higher MPO protein or markers of lipid oxidation on the Cardio Zoomer panel. Elevated genetic tendency should be interpreted in the context of the full biomarker profile and clinical information.

Why is MPO – rs2107545 included in the Cardio Zoomer?

Including this MPO variant adds inherited context to measures of inflammation and oxidative stress. It helps clinicians link genetic tendency with circulating MPO, oxidized lipids, and inflammatory markers so they can better understand drivers of cardiovascular-related biomarker patterns and personalize monitoring and prevention strategies.

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