MTP – rs1800591 is a single nucleotide polymorphism (SNP) in the regulatory region of the microsomal triglyceride transfer protein (MTP) gene. MTP is an endoplasmic‑reticulum protein that transfers triglycerides and other lipids onto apolipoprotein B, a key step in forming VLDL and chylomicrons. The rs1800591 change is a common promoter variant that can alter MTP expression in liver and gut cells. This variant was identified in genetic and population studies that examined lipid traits and liver fat distribution. While not diagnostic on its own, rs1800591 is clinically relevant because differences in MTP activity influence how much lipid is secreted into blood versus retained in tissues, affecting patterns seen across other lipid and metabolic biomarkers measured in modern cardiovascular panels.

When discussed as “higher” or “lower” activity tied to rs1800591, increased MTP expression or function is typically associated with greater secretion of triglyceride‑rich lipoproteins, which may show as higher circulating triglycerides or altered LDL composition on a lipid profile. Lower MTP expression or function is associated with reduced lipoprotein export and may coincide with lipid retention in liver or changes in ApoB‑related measures. Interpretation requires the full Cardio Zoomer context—lipid subfractions, ApoB, LFTs, inflammatory and oxidative markers—to understand whether the genetic pattern aligns with current lab findings and clinical risk patterns.

Cardio Zoomer includes rs1800591 to capture an inherited influence on lipid assembly and export. This marker helps explain individual differences in triglyceride and ApoB patterns, complements biochemical measures, and provides a genetic lens that can refine risk pattern interpretation and personalized prevention planning.